Results 221 to 230 of about 136,601 (268)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Extremophile hotspots linked to containerized industrial waste dumping in a deep-sea basin. [PDF]

PNAS Nexus
Gutleben J, Podell S, Mizell K, Sweeney D, Neira C, Levin LA, Jensen PR.   +6 more
europepmc   +1 more source

A Sea of Voices: Deep sea mining and the Solwara 1 Project in Papua New Guinea

, 2019
Hayley Phillips
openalex   +1 more source

Automated recognition of deep-sea benthic megafauna in polymetallic nodule mining areas based on deep learning

Geoff Long, Wei Song, Xiangchun Liu, Ziyao Fang, Jing An, Kun Liu, Yaqin Huang, Xuebao He   +7 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

From Deep-Sea Natural Product to Optimized Therapeutics: Computational Design of Marizomib Analogs. [PDF]

Int J Mol Sci
Alotaiq N, Dermawan D.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Temperature and Pressure Shaped the Evolution of Antifreeze Proteins in Polar and Deep Sea Zoarcoid Fishes. [PDF]

Mol Biol Evol
Bogan SN, Surendran N, Hotaling S, Desvignes T, Bista I, Lins LSF, Eilertsen MH, Le François NR, Algayer T, Hamilton SL, Frandsen PB, Hoffmann FG, Kelley JL.   +12 more
europepmc   +1 more source

Biogeography of Persephonella in deep-sea hydrothermal vents of the Western Pacific.

, 2013
Sayaka eMino, Hiroko eMaikita, Tomohiro eToki, Junichi eMiyazaki, Shingo eKato, Hiromi eWatanabe, Hiroyuki eImachi, Tomo-o eWatsuji, Takuro eNunoura, Shigeaki eKojima, Tomoo eSawabe, Ken eTakai, Satoshi eNakagawa   +12 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source