Results 61 to 70 of about 103,225 (263)

Advancing instantaneous detonation prediction of condensed energetic materials based on high-order compressible multiphase fluid dynamics

AIP Advances
The instantaneous detonation model (IDM) is widely used in simulating underwater explosions due to its efficiency and ability to ignore the detonation reaction process.
Yi Hao, Jun Wang, Jiping Chen, Zhenxin Sheng, Guozhen Liu, Jun Yu   +5 more
doaj   +1 more source

Survival strategies for the microbiome in a vent-dwelling glass sponge from the middle Okinawa Trough

Frontiers in Microbiology
The adaptive mechanisms of sponge microbiomes to harsh deep-sea environments, including hydrothermal vents and cold seeps, remain unclear. Here, we used metagenomics to investigate the microbiome of an undescribed vent-dwelling glass sponge from the ...
Yu-Hang Li, Yu-Hang Li, Yu-Hang Li, Ming Yang, Ming Yang, Ming Yang, Tao-Shu Wei, Tao-Shu Wei, Hua-Guan Chen, Hua-Guan Chen, Lin Gong, Yong Wang, Zhao-Ming Gao, Zhao-Ming Gao, Zhao-Ming Gao   +14 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The complete mitochondrial genome of the vent snail Phymorhynchus sp. (Gastropoda: Raphitomidae)

Mitochondrial DNA. Part B. Resources, 2020
We first determined the complete mitochondrial genome of Phymorhynchus sp. in this study. The total length of the mitochondrial genome of Phymorhynchus sp.
Lvpei Du, Shanya Cai, Jun Liu, Haibin Zhang   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Carbon-silicon species are unlikely in subduction-zone fluids

Communications Earth & Environment
In subduction zones, carbon-bearing fluids play a pivotal role in deep carbon cycling and global climate change. Given that Earth’s interior is dominated by silicates, the existence of aqueous carbon-silicon (C-Si) species is crucial for assessing the ...
Nanfei Cheng, I-Ming Chou, Ying Chen, Zhenhao Duan, Xiaolin Wang, Hao Yan   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source