Results 111 to 120 of about 40,219 (304)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Continuous Deep Sedation Until Death—a Swiss Death Certificate Study [PDF]

, 2018
Sarah Ziegler, Margareta Schmid, Matthias Bopp, Georg Bosshard, Milo A. Puhan   +4 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Comparison of the effects of general anesthesia and deep sedation on anesthesia complications and mortality in endoscopic retrograde cholangiopancreatography procedures

, 2023
Elif Büyükerkmen, Ahmet Yüksek, Elif Doğan Bakı, Sezgin Yılmaz   +3 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Clinical Impact of Local Anesthesia on Sedation Stability and Propofol Dosage in Pediatric Dental Sedation

European Annals of Dental Sciences
Background: Local anesthesia (LA) is often preferred for stabilization of vital signs, depth of anesthesia and pain control in dental restorations but the efficacy of LA administration during deep sedation is controversial.Aim ...
Merve Hayriye Kocaoglu, Çağıl Vural, Betül Büşra Ursavaş   +2 more
doaj   +1 more source

Comparison of efficacy and recovery time of sevoflurane inhalation deep sedation with propofol deep sedation in pediatric dentistry [PDF]

, 2022
Mhd Raslan Alzein, Mohamed Altinawi, Faten Rostom, Imad Katbeh, Mamasaidova Zarina, Saidova Patimat   +5 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Procedural sedation analgesia

Saudi Journal of Anaesthesia, 2010
The number of noninvasive and minimally invasive procedures performed outside of the operating room has grown exponentially over the last several decades.
Sheta Saad
doaj