Results 161 to 170 of about 240,619 (265)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR. [PDF]

Elife
Gustafsson HT, Ferguson L, Galan C, Yu T, Upton H, Kaymak E, Weng Z, Collins K, Rando OJ.   +8 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Deep sequencing of 16 <i>Ixodes ricinus</i> ticks unveils insights into their interactions with endosymbionts. [PDF]

mSystems
Lesiczka PM, Azagi T, Krawczyk AI, Scott WT, Dirks RP, Simo L, Dobler G, Nijsse B, Schaap PJ, Sprong H, Koehorst JJ.   +10 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Deep sequencing of circulating tumour DNA as a biomarker of clinical outcome to transarterial chemoembolisation in hepatocellular carcinoma. [PDF]

NPJ Precis Oncol
Sharma R, Alharbi SN, Ellum K, Motedayen-Aval L, Casadei-Gardini A, Pinato DJ, Bettinger D, Bengsch B, Patel R, Evans J.   +9 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Correction to "Use of Deep Sequencing to Evaluate Transitions in Microbial Communities in Stranded <i>Sargassum</i>". [PDF]

Int J Microbiol
europepmc   +1 more source

Deep sequencing as a diagnostic tool in patients with suspected primary vitreoretinal lymphoma. [PDF]

Br J Ophthalmol
Choo C, Cote O, Bostwick K, Regueiro M, Wells J, Grossniklaus HE, Gonzales J, Yeh S, Hinterwirth A, Doan T, Shantha JG.   +10 more
europepmc   +1 more source