Results 161 to 170 of about 240,068 (314)

Immune Repertoire Deep Sequencing [PDF]

, 2020
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Benchmarking UMI clustering tools for accurate detection of low-frequency variants from deep sequencing. [PDF]

Sci Rep
Pu D, Li J, Li J, Qin S, Qiu X, Wang Z, Shu K.   +6 more
europepmc   +1 more source

Characterization of microRNA transcriptome in lung cancer by next‐generation deep sequencing

, 2014
Jie Ma, Kaiissar Mannoor, Lu Gao, Afang Tan, Maria Guarnera, Min Zhan, Amol C. Shetty, Sanford A. Stass, Lingxiao Xing, Feng Jiang   +9 more
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Naturally Circulating Hepatitis A Virus in Olive Baboons, Uganda

Emerging Infectious Diseases, 2016
Andrew J. Bennett, Samuel D. Sibley, Michael Lauck, Geoffrey Weny, David Hyeroba, Alex Tumukunde, Thomas C. Friedrich, David H. O’Connor, Caley A. Johnson, Jessica M. Rothman, Tony L. Goldberg   +10 more
doaj   +1 more source

Protocol for the recovery and deep sequencing of short ssDNA pools from transient, fuel-dependent coacervate droplets. [PDF]

STAR Protoc
Holtmannspötter AL, Machatzke C, Boekhoven J, Mutschler H.   +3 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Targeted virome deep sequencing reveals frequent herpesvirus detection in intestinal biopsies of inflammatory bowel disease patients. [PDF]

PLoS One
Vásquez JN, Doncel P, Camacho J, Ruiz E, Recio V, Tarragó D.   +5 more
europepmc   +1 more source

Deep learning for biological sequences

, 2020
72
openaire   +1 more source