Results 171 to 180 of about 240,068 (314)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing. [PDF]

J Pathol
Andersson N, Ferro M, Jansson C, Chattopadhyay S, Karlsson J, Gisselsson D.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Use of Deep Sequencing to Evaluate Transitions in Microbial Communities in Stranded <i>Sargassum</i>. [PDF]

Int J Microbiol
Abdool-Ghany AA, Babler KM, Bogumil D, Pollock S, Li J, Manning SR, Solo-Gabriele HM.   +6 more
europepmc   +1 more source

Somatic copy number alterations detected by ultra-deep targeted sequencing predict prognosis in oral cavity squamous cell carcinoma [PDF]

, 2015
Chien-Hua Peng, Chun‐Ta Liao, Ka-Pou Ng, An‐Shun Tai, Shih-Chi Peng, Jen-Pao Yeh, Shu‐Jen Chen, Kuo‐Chien Tsao, Tzu‐Chen Yen, Wen‐Ping Hsieh   +9 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

ViralBottleneck: an R package for estimating viral transmission bottlenecks from deep sequencing data using multiple methods. [PDF]

Virus Evol
Zheng B, Johnson PCD, Hughes J.
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Deep Sequencing Reveals Novel Mutations in <i>Androgen Receptor</i>-Related Genes in Prostate Cancer. [PDF]

Int J Mol Sci
Pedroza-Torres A, Baranda-Avila N, Ramírez JL, González M, González PA, Torres BL, Jiménez-Ríos MA, Méndez-Tenorio A, Álvarez-Gómez RM, Hernández G.   +9 more
europepmc   +1 more source