Results 201 to 210 of about 240,068 (314)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Deep Sequencing Analysis of Hepatitis C Virus Subtypes and Resistance-Associated Substitutions in Genotype 4 Patients Resistant to Direct-Acting Antiviral (DAA) Treatment in Egypt. [PDF]

Int J Mol Sci
Garcia-Cehic D, Mosbeh A, A Gad H, Gomaa AI, Ibañez Lligoña M, Gregori J, Colomer-Castell S, Campos C, Rodriguez-Frias F, Esteban JI, Kohla MS, Abdel-Rahman MH, Quer J.   +12 more
europepmc   +1 more source

Additional file 5: Table S4. of Identification of conserved and novel microRNAs in Porphyridium purpureum via deep sequencing and bioinformatics

, 2016
Fan Gao, Fangru Nan, Jia Feng, Junping Lv, Qi Liu, Shulian Xie   +5 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Deep Sequencing of Crohn's Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression. [PDF]

Inflamm Bowel Dis
Jacobsen GE, Gonzalez EE, Mendygral P, Faust KM, Hazime H, Fernandez I, Santander AM, Quintero MA, Jiang C, Damas OM, Deshpande AR, Kerman DH, Proksell S, Sendzischew Shane M, Sussman DA, Ghaddar B, Cickovsk T, Abreu MT.   +17 more
europepmc   +1 more source

Case Report: Whole genome sequencing identifies a novel deep intronic COL4A5 variant of uncertain significance in X-linked Alport syndrome [PDF]

Hoon Seok Kim, Myungshin Kim, Jin‐Soon Suh, Yeon Hee Lee   +3 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Identification of Genomic Structural Variations in Xinjiang Brown Cattle by Deep Sequencing and Their Association with Body Conformation Traits. [PDF]

Int J Mol Sci
Wang D, Zhang T, Zhang M, Chen Q, Yan M, Ma S, Wang J, Zhang X, Ma K, Xu L, Huang X.   +10 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Additional file 2: of Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections

, 2017
Anita Lerch, Cristian Koepfli, Natalie Hofmann, Camilla Messerli, Stephen Wilcox, Johanna Helena Kattenberg, Inoni Betuela, Liam O’Connor, Ivo Müeller, Ingrid Felger   +9 more
openalex   +1 more source