Results 51 to 60 of about 802,741 (299)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A methodology to support strategic decisions in future human space exploration: from scenario definition to building blocks assessment [PDF]

, 2013
The human exploration of multiple deep space destinations (e.g. Cis-Lunar, NEAs), in view of the final challenge of sending astronauts to Mars, represents a current and consistent study domain especially in terms of its possible scenarios and mission ...
Andrea Messidoro, Eugenio Gargioli, Jeffrey A. Hoffman, Maria Antonietta Viscio, Nicole Viola, Paolo Maggiore, Salotti, Salotti, Zubrin   +8 more
core   +1 more source

Control-Oriented Deep Space Communications for Unmanned Space Exploration

IEEE Transactions on Wireless Communications
In unmanned space exploration, the cooperation among space robots requires advanced communication techniques. In this paper, we propose a communication optimization scheme for a specific cooperation system named the "mother-daughter system". In this setup, the mother spacecraft orbits the planet, while daughter probes are distributed across the ...
Xinran Fang, Wei Feng, Yunfei Chen, Ning Ge, Gan Zheng   +4 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Extra-terrestrial construction processes - advancements, opportunities and challenges

, 2017
Government space agencies, including NASA and ESA, are conducting preliminary studies on building alternative space-habitat systems for deep-space exploration.
Anand, Mahesh, Levin Prabhu, Vibha, Lim, Sungwoo, Taylor, Lawrence   +3 more
core   +1 more source

A Novel Approach for Permittivity Estimation of Lunar Regolith Using the Lunar Penetrating Radar Onboard Chang’E-4 Rover

Remote Sensing, 2021
Accurate relative permittivity is essential to the further analysis of lunar regolith. The traditional hyperbola fitting method for the relative permittivity estimation using the lunar penetrating radar generally ignored the effect of the position and ...
Ruigang Wang, Yan Su, Chunyu Ding, Shun Dai, Chendi Liu, Zongyu Zhang, Tiansheng Hong, Qing Zhang, Chunlai Li   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploring Restart Distributions [PDF]

, 2019
We consider the generic approach of using an experience memory to help exploration by adapting a restart distribution. That is, given the capacity to reset the state with those corresponding to the agent's past observations, we help exploration by ...
Islam, Riashat, Kormushev, Petar, Levdik, Vitaly, Smith, Christopher M., Tavakoli, Arash   +4 more
core   +1 more source

The Temporal Variation of Optical Depth in the Candidate Landing Area of China’s Mars Mission (Tianwen-1)

Remote Sensing, 2021
The atmospheric dust is an important factor in the evolution of the Martian climate and has a major impact on the scientific exploration of the Martian lander or rover and its payload.
Zhencheng Tang, Jianjun Liu, Xing Wang, Xin Ren, Wei Yan, Wangli Chen   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source