Results 61 to 70 of about 91,562 (307)

Bio-inspired Chemical Space Exploration of Terpenoids

, 2022
Many computational methods are used to expand the open-ended border of chemical spaces. Natural products and their derivatives are an important source for drug discovery, and some algorithms are devoted to rapidly generating pseudo-natural products ...
fan, zhang, tao, zeng, B. Andes, Hess, ruibo, wu   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Novel Approach for Permittivity Estimation of Lunar Regolith Using the Lunar Penetrating Radar Onboard Chang’E-4 Rover

Remote Sensing, 2021
Accurate relative permittivity is essential to the further analysis of lunar regolith. The traditional hyperbola fitting method for the relative permittivity estimation using the lunar penetrating radar generally ignored the effect of the position and ...
Ruigang Wang, Yan Su, Chunyu Ding, Shun Dai, Chendi Liu, Zongyu Zhang, Tiansheng Hong, Qing Zhang, Chunlai Li   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Temporal Variation of Optical Depth in the Candidate Landing Area of China’s Mars Mission (Tianwen-1)

Remote Sensing, 2021
The atmospheric dust is an important factor in the evolution of the Martian climate and has a major impact on the scientific exploration of the Martian lander or rover and its payload.
Zhencheng Tang, Jianjun Liu, Xing Wang, Xin Ren, Wei Yan, Wangli Chen   +5 more
doaj   +1 more source

Deep Coherent Exploration For Continuous Control [PDF]

, 2021
In policy search methods for reinforcement learning (RL), exploration is often performed by injecting noise either in action space at each step independently or in parameter space over each full trajectory.
Zhang, Y., van Hoof, H.
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Evidence of water on the lunar surface from Chang’E-5 in-situ spectra and returned samples

Nature Communications, 2022
Laboratory analysis of returned Chang’E-5 samples from the lunar surface show their hydroxyl contents to be on the weak end of lunar hydration features.
Jianjun Liu, Bin Liu, Xin Ren, Chunlai Li, Rong Shu, Lin Guo, Songzheng Yu, Qin Zhou, Dawei Liu, Xingguo Zeng, Xingye Gao, Guangliang Zhang, Wei Yan, Hongbo Zhang, Lihui Jia, Shifeng Jin, Chunhua Xu, Xiangjin Deng, Jianfeng Xie, Jianfeng Yang, Changning Huang, Wei Zuo, Yan Su, Weibin Wen, Ziyuan Ouyang   +24 more
doaj   +1 more source

Machine Learning Fusion Multi-Source Data Features for Classification Prediction of Lunar Surface Geological Units

Remote Sensing, 2022
Taking the Chang’e-4 and Chang’e-5 landing areas as the study areas, this study extracts the geological unit information from the regional USGS geological map, as well as the feature information such as topography and geomorphology, material composition ...
Wei Zuo, Xingguo Zeng, Xingye Gao, Zhoubin Zhang, Dawei Liu, Chunlai Li   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source