Results 81 to 90 of about 7,150,509 (282)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Formation of Lunar Swirls: Implication from Derived Nanophase Iron Abundance

Remote Sensing
Lunar swirls are enigmatic features on the Moon’s surface, and their formation remains debated. Previous studies suggest that the distinctive spectral characteristics of lunar swirls result from the asymmetric space weathering between their bright ...
Wanqi Zhao, Xin Ren, Bin Liu, Yao Xiao, Dawei Liu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and mechanical behavior of ice-cemented Martian Regolith Simulant (TJ-MRS01) for future mars sample-return engineering studies

Earth, Planets and Space
Ice-cemented regolith exists on Mars and could significantly influence surface mechanical behavior, affecting drilling, mobility, and sample acquisition strategies.
Siji Sanlang, Kaihan Xu, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Xiong Xu, Yusheng Xu   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Retrieving water ice abundance in representative regions of the Moon’s South Pole using topography corrected SELENE MI images

Geoscience Letters
Previous studies have reported the existence of water ice in the lunar polar regions, but estimations of water ice using different methods vary in certainty, precision, location, and abundance.
Xindi Long, Chao Wang, Siji Sanlang, Yongjiu Feng, Xiong Xu, Huan Xie, Xiaohua Tong   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

First Report of Rising‐Tone EMIC Waves Driven by the Magnetosheath High‐Speed Jet

Geophysical Research Letters
Magnetosheath high‐speed jets (HSJs) are pervasive transient structures with enhanced dynamic pressure in the terrestrial magnetosheath and can exert notable local impacts on the magnetopause.
Wentian Lei, Xinliang Gao, Xuan Zhou, Jiuqi Ma, Tong Shao, Yuxiang Wang, Quanming Lu   +6 more
doaj   +1 more source

Evaluation of deep space exploration risks and mitigations against radiation and microgravity. [PDF]

Front Nucl Med, 2023
Dobney W, Mols L, Mistry D, Tabury K, Baselet B, Baatout S.   +5 more
europepmc   +1 more source

High Altitude Skydiving Apparatus

, 2022
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
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