Results 81 to 90 of about 91,562 (307)
Morphology exploration of pollen using deep learning latent space
, 2023 The structure of pollen has evolved depending on its local environment, competition, and ecology. As pollen grains are generally of size 10–100 microns with nanometre-scale substructure, scanning electron microscopy is an important microscopy technique ...
Grant-Jacob, James +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Next space exploration step: human expeditions to Libration points
, 2012 The next step in the human space exploration is to travel beyond Low Earth Orbit and in this regard the Earth-Moon Lagrangian points represent an interesting and logical first destination.
VISCIO, MARIA ANTONIETTA +6 more
core
Prospect on Application of Deep-Sea Engineering Technology in Deep-Space Exploration
With the further development of deep-space, deep-sea, and deep-ground technologies, numerous technical connections are found existing between deep-sea engineering and deep-space exploration and thus it is feasible to apply deep-sea engineering ...
Yanqing Li +6 more
core +1 more source
, 2023 Current scientific developments have reached the stage where human aspirations of space exploration are not science fiction but a reality involving travelling to the Earth’s orbit, the Moon and Mars.
David W. Kim
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Future Human Space Exploration: key technologies assessment and applicability analysis
, 2012 The paper deals with the assessment of the key technologies needed for future space exploration missions. A human expedition to Mars is so far considered the most interesting target for the future Human Space Exploration (HSE).
Maggiore, Paolo +6 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
With the development of technology and methodologies, Raman spectrometers are becoming efficient candidate payloads for planetary materials characterizations in deep space exploration missions.
Ayang Xiao +5 more
core +1 more source