Results 91 to 100 of about 7,150,509 (282)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

3D Discrete element method modeling of the cone penetration test in lunar regolith simulant with various internal friction angles

Geo-spatial Information Science
The mechanical behavior of lunar regolith is highly influenced by its diverse mechanical properties, which are critical for geotechnical engineering activities during lunar exploration missions.
Siji Sanlang, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Jia Li, Mingjing Jiang, Xiong Xu, Yanmin Jin   +8 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Human behavior and performance in deep space exploration: next challenges and research gaps. [PDF]

NPJ Microgravity, 2023
Pagnini F, Manzey D, Rosnet E, Ferravante D, White O, Smith N.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration. [PDF]

NPJ Microgravity, 2023
Liphardt AM, Fernandez-Gonzalo R, Albracht K, Rittweger J, Vico L.   +4 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

Earth and Planetary Physics
The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly understood. In this article, we present an electron current layer detected at the edge of the magnetotail plasma sheet.
ChenChen Zhan, RongSheng Wang, QuanMing Lu, San Lu, XinMin Li   +4 more
doaj   +1 more source

Off-World Mental Health: Considerations for the Design of Well-being-Supportive Technologies for Deep Space Exploration. [PDF]

JMIR Form Res, 2023
Smith N, Peters D, Jay C, Sandal GM, Barrett EC, Wuebker R.   +5 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source