Results 91 to 100 of about 91,562 (307)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Formation of Lunar Swirls: Implication from Derived Nanophase Iron Abundance

Remote Sensing
Lunar swirls are enigmatic features on the Moon’s surface, and their formation remains debated. Previous studies suggest that the distinctive spectral characteristics of lunar swirls result from the asymmetric space weathering between their bright ...
Wanqi Zhao, Xin Ren, Bin Liu, Yao Xiao, Dawei Liu   +4 more
doaj   +1 more source

A Review of Deep Space Image-Based Navigation Methods

Deep space exploration missions face technical challenges such as long-distance communication delays and high-precision autonomous positioning. Traditional ground-based telemetry and control as well as inertial navigation schemes struggle to meet mission
Chunhui Zhao, Lin Li, Xiaoyi Lin, Tao Li, Baocheng Hua   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and mechanical behavior of ice-cemented Martian Regolith Simulant (TJ-MRS01) for future mars sample-return engineering studies

Earth, Planets and Space
Ice-cemented regolith exists on Mars and could significantly influence surface mechanical behavior, affecting drilling, mobility, and sample acquisition strategies.
Siji Sanlang, Kaihan Xu, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Xiong Xu, Yusheng Xu   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Retrieving water ice abundance in representative regions of the Moon’s South Pole using topography corrected SELENE MI images

Geoscience Letters
Previous studies have reported the existence of water ice in the lunar polar regions, but estimations of water ice using different methods vary in certainty, precision, location, and abundance.
Xindi Long, Chao Wang, Siji Sanlang, Yongjiu Feng, Xiong Xu, Huan Xie, Xiaohua Tong   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

3D Discrete element method modeling of the cone penetration test in lunar regolith simulant with various internal friction angles

Geo-spatial Information Science
The mechanical behavior of lunar regolith is highly influenced by its diverse mechanical properties, which are critical for geotechnical engineering activities during lunar exploration missions.
Siji Sanlang, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Jia Li, Mingjing Jiang, Xiong Xu, Yanmin Jin   +8 more
doaj   +1 more source

Evaluation of deep space exploration risks and mitigations against radiation and microgravity. [PDF]

Front Nucl Med, 2023
Dobney W, Mols L, Mistry D, Tabury K, Baselet B, Baatout S.   +5 more
europepmc   +1 more source