Results 91 to 100 of about 802,741 (299)

Capabilities Development: From International Space Station and the Moon to Mars [PDF]

open access: yes
The President of the United States, in signing Space Policy Directive-1, directed the NASA Administrator to lead an innovative and sustainable program of exploration with commercial and international partners to enable human expansion across the solar ...
Boggs, Kathleen Gallagher   +2 more
core   +1 more source

DOP: Deep Optimistic Planning with Approximate Value Function Evaluation [PDF]

open access: yes, 2018
Research on reinforcement learning has demonstrated promising results in manifold applications and domains. Still, efficiently learning effective robot behaviors is very difficult, due to unstructured scenarios, high uncertainties, and large state ...
Capobianco, Roberto   +2 more
core  

Formation of Lunar Swirls: Implication from Derived Nanophase Iron Abundance

open access: yesRemote Sensing
Lunar swirls are enigmatic features on the Moon’s surface, and their formation remains debated. Previous studies suggest that the distinctive spectral characteristics of lunar swirls result from the asymmetric space weathering between their bright ...
Wanqi Zhao   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A Control Framework for Autonomous Smart Grids for Space Power Applications [PDF]

open access: yes
With the National Aeronautics and Space Administration's (NASA) rising interest in lunar surface operations and deep space exploration, there is a growing need to move from traditional ground-based mission operations to more autonomous vehicle level ...
Carbone, Marc A.
core   +1 more source

Retrieving water ice abundance in representative regions of the Moon’s South Pole using topography corrected SELENE MI images

open access: yesGeoscience Letters
Previous studies have reported the existence of water ice in the lunar polar regions, but estimations of water ice using different methods vary in certainty, precision, location, and abundance.
Xindi Long   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hands-Free Control Interfaces for an Extra Vehicular Jetpack [PDF]

open access: yes, 2012
The National Aeronautics and Space Administration (NASA) strategic vision includes, as part of its long-term goals, the exploration of deep space and Near Earth Asteroids (NEA).
Curiel, Pedro H.   +2 more
core   +1 more source

3D Discrete element method modeling of the cone penetration test in lunar regolith simulant with various internal friction angles

open access: yesGeo-spatial Information Science
The mechanical behavior of lunar regolith is highly influenced by its diverse mechanical properties, which are critical for geotechnical engineering activities during lunar exploration missions.
Siji Sanlang   +8 more
doaj   +1 more source

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