Results 71 to 80 of about 91,562 (307)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geological characteristics of Chang’E-6 landing area in micro-scale unveiled by new observation data
Nature CommunicationsChang’E-6 mission successfully achieved humanity’s first sample return from the farside of the Moon. Here, we report a high-precision terrain dataset with millimeter-to-decimeter spatial resolution around the CE-6 landing site. Based on this dataset, the
Wei Yan +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
International Journal of Antennas and Propagation, 2017 In the process of lunar exploration, and specifically when studying lunar surface structure and thickness, the established lunar regolith model is usually a uniform and ideal structural model, which is not well-suited to describe the real structure of ...
Chunyu Ding +7 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Anomaly Detection Method for Harmonic Reducers with Only Healthy Data
SensorsA harmonic reducer is an important component of industrial robots. In practical applications, it is difficult to obtain enough anomaly data from error cases for the supervised training of models.
Yuqing Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Static effects of differential rotation on Jupiter’s shape, gravity field, and interior structure
Astronomy & AstrophysicsContext. Jupiter’s atmosphere has strong zonal flows and exhibits marked differential rotation. The dynamic effects of these flows on Jupiter’s gravity field and internal structure have been extensively investigated in order to interpret Juno gravity ...
Luo Song, Jia Chaonan, Ni Dongdong
doaj +1 more source
Chemical space exploration guided by deep neural networks
RSC Advances, 2019 A parametric t-SNE approach based on deep feed-forward neural networks was applied to the chemical space visualization problem.
Dmitry S. Karlov +3 more
openaire +4 more sources