Results 51 to 60 of about 201,281 (284)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Polarization control proposal for Shanghai deep ultraviolet free electron laser

, 2012
In this paper, a fully coherent radiation option with controllable polarization is proposed for Shanghai deep ultraviolet free electron laser (FEL) test facility.
Allaria, Bahrdt, Bo Liu, Born, Chao Feng, Chapman, Deng, Ding, Dong Wang, Emma, Faatz, Feng, Geng, Glownia, Haixiao Deng, Jianhui Chen, Kim, Kim, Li, Lie Feng, Litvinenko, Meng Zhang, Miao Zhang, Reiche, Saldin, Shigemi, Taihe Lan, Tiedtke, Tong Zhang, Wu, Wu, Xingtao Wang, Yan, Yu, Zhao, Zhimin Dai   +35 more
core   +1 more source

The Bright Ages Survey. II. Evolution of Luminosity, Dust Extinction, and Star Formation from z = 0.5 to z = 2.5 [PDF]

, 2006
The Bright Ages Survey is a K-band-selected redshift survey over six separate fields with UBVRIzJHK imaging covering a total of 75.6 arcmin(2) and reaching K = 20-20.5. Two fields have deep HST imaging, while all are centered on possible overdensities in
Colbert, James W., Malkan, Matthew A., Rich, R. Michael   +2 more
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Evidence for a Gradual Decline in the Universal Rest-Frame UV Luminosity Density for z < 1

, 1999
We have utilized various magnitude-limited samples drawn from an extremely deep and highly complete spectroscopic redshift survey of galaxies observed in seven colors in the Hawaii Survey Fields and the Hubble Deep Field to investigate the evolution of ...
Amy J. Barger, Antoinette Songaila, Ellis R. S., Lennox L. Cowie, Madau P.   +4 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Intelligent Recognition of Insulator Contamination Grade Based on the Deep Learning of Ultraviolet Discharge Image Information

Energies, 2020
In order to achieve the noncontact detection of the contamination grade of insulators and to provide guidance for preventing the contamination flashover of insulators based on the pollution state, we propose a contamination grade recognition method based
Da Zhang, Shuailin Chen
doaj   +1 more source

Ultraviolet number counts of galaxies from Swift UV/Optical Telescope deep imaging of the Chandra Deep Field South

, 2009
Deep Swift UV/Optical Telescope (UVOT) imaging of the Chandra Deep Field South is used to measure galaxy number counts in three near ultraviolet (NUV) filters (uvw2: 1928 A, uvm2: 2246 A, uvw1: 2600 A) and the u band (3645 A). UVOT observations cover the
A. A. Breeveld, Arnouts, Baldry, Beckwith, C. Gronwall, Capak, D. A. Hinshaw, D. E. Vanden Berk, Deharveng, E. A. Hoversten, Eddington, Eliche-Moral, F. E. Marshall, Fioc, Gardner, Gehrels, Giacconi, Giavalisco, Lehmer, M. H. Siegel, M. Still, P. A. Curran, P. W. A. Roming, Poole, Sasseen, Schlegel, Smail, T. S. Koch, Teplitz, Trenti, Volonteri, Wyder, Xu, Yasuda   +33 more
core   +1 more source

The Stellar Initial Mass Function at the Epoch of Reionization [PDF]

, 2008
I provide estimates of the ultraviolet and visible light luminosity density at z~6 after accounting for the contribution from faint galaxies below the detection limit of deep Hubble and Spitzer surveys.
Dave R., Eyles L., Ranga‐Ram Chary, Tornatore L.   +3 more
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source