Results 101 to 110 of about 2,478,930 (305)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Progress and Perspectives on Pyrite-Derived Materials Applied in Advanced Oxidation Processes for the Elimination of Emerging Contaminants from Wastewater

Molecules
Emerging contaminants (ECs) in wastewater threaten environmental and human health, while conventional methods often prove inadequate. This has driven increased concern among decision makers, justifying the need for innovative and effective treatment ...
Jannat Javed, Yuting Zhou, Saad Ullah, Tianjiu Gao, Caiyun Yang, Ying Han, Hao Wu   +6 more
doaj   +1 more source

Water wave collapses over quasi-one-dimensional non-uniformly periodic bed profiles

, 2009
Nonlinear water waves interacting with quasi-one-dimensional, non-uniformly periodic bed profiles are studied numerically in the deep-water regime with the help of approximate equations for envelopes of the forward and backward waves.
Ruban, V. P.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A new species of deep-water Holothuroidea (Echinodermata) of the genus Synallactes from off western Mexico

Scientia Marina, 2010
An undescribed species of Synallactes was collected during a deep-water benthic fauna survey off the Pacific coast of Mexico in the East Pacific, with the R/V El Puma.
Claude Massin, Michel E. Hendrickx
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Experimental and simulation studies on damage characteristics, crack development patterns, and strength reduction mechanisms of sandstone under laser irradiation

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In order to explore the damage characteristics and crack development laws of hard rock under laser irradiation, laser irradiation experiments on sandstone were conducted considering the interaction of three laser parameters: spot diameter, laser power ...
Junjun Liu, Chuo Zhang, Lei Yang, Xuemin Zhou, Jing Xie, Bengao Yang, Zhiqiang He, Mingzhong Gao   +7 more
doaj   +1 more source

Experimental Studies to Evaluate the Effects of Different Unloading Stress Paths on Strength Properties of Unconsolidated Sands

Geosciences
The mechanical behavior of rocks under loading conditions depends on stress path and magnitude. With increasing load, rocks have an elasto-plastic behavior.
Sabyasachi Prakash, Michael Myers, George Wong, Lori Hathon, Duane Mikulencak   +4 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source