Results 41 to 50 of about 10,020,504 (351)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A new species of Acteon (Opisthobranchia: Acteonidae) from Northeast Brazil
Zoologia (Curitiba), 2011 A new species of Acteon Montfort 1810, Acteon mirim sp. nov., from Canopus Bank, state of Ceará, Brazil is described based on shell morphology. The new species is compared with other species of the genus reported from Brazil.
Carlo Magenta Cunha
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Recoil Control Analysis of Deepwater Drilling Riser Tension System
Shiyou jixie, 2020 The drilling riser tension system can mitigate the influence of the floating platform/ship heave motion on the riser and provide a nearly constant top tension force for the riser. Therefore, a large amount of energy is stored in the drilling riser system.
Sun Zhanguang +5 more
doaj
Review of research in internal-wave and internal-tide deposits of China: Discussion
Journal of Palaeogeography, 2014 This discussion of a review article by [27], published in the Journal of Palaeogeography (2(1): 56– 65), is aimed at illustrating that interpretations of ten ancient examples in China and one in the central Appalachians (USA) as deep-water deposits of ...
G. Shanmugam
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Development of Engineering Prototype of Deep-Water Split Submarine PLET
Shiyou jixie, 2020 The PLET is the core product of deep-water oil and gas field development, whose technologies have long been monopolized by foreign countries. To master the key technologies for the design, manufacture, testing and installation of deep-water PLET and ...
石磊 +4 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
EnergiesThis study investigates the flow and heat transfer mechanisms of high-temperature air flowing across staggered lined fine tubes in a SABRE-type precooler.
Qinyi Zhang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source