Results 21 to 30 of about 59,651 (231)

Prion replication in organotypic brain slice cultures is distinct from in vivo inoculation and is species dependent. [PDF]

Acta Neuropathol Commun
Cultured brain slices rapidly replicate murine prions, exhibit prion pathology, and are amenable towards drug discovery, but have not been infected with human prions.
Slota JA, Lamoureux L, Myskiw J, Frost KL, Medina SJ, Kielich DMS, Leonhardt M, Thapar G, Bailey-Elkin BA, Booth SA.   +9 more
europepmc   +2 more sources

SARS-CoV-2 infects multiple species of North American deer mice and causes clinical disease in the California mouse

Frontiers in Virology, 2023
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease-19 (COVID-19), emerged in late 2019 in Wuhan, China and its rapid global spread has resulted in millions of deaths.
Juliette Lewis, Shijun Zhan, Allison C. Vilander, Anna C. Fagre, Tawfik A. Aboellail, Hippokratis Kiaris, Tony Schountz   +6 more
doaj   +1 more source

Generation of competent bone marrow-derived antigen presenting cells from the deer mouse (Peromyscus maniculatus)

BMC Immunology, 2004
Background Human infections with Sin Nombre virus (SNV) and related New World hantaviruses often lead to hantavirus cardiopulmonary syndrome (HCPS), a sometimes fatal illness.
Farrell Regina M, Prescott Joseph, Willis Derall G, Davenport Bennett J, Coons Teresa A, Schountz Tony   +5 more
doaj   +1 more source

Sin nombre virus and rodent species diversity: a test of the dilution and amplification hypotheses. [PDF]

PLoS ONE, 2009
BACKGROUND:Species diversity is proposed to greatly impact the prevalence of pathogens. Two predominant hypotheses, the "Dilution Effect" and the "Amplification Effect", predict divergent outcomes with respect to the impact of species diversity.
Christine A Clay, Erin M Lehmer, Stephen St Jeor, M Denise Dearing   +3 more
doaj   +1 more source

Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus

Viruses, 2019
In North America, Sin Nombre virus (SNV) is the main cause of hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with a fatality rate of 35⁻40%. SNV is a zoonotic pathogen carried by deer mice (Peromyscus maniculatus), and few
Bryce M. Warner, Derek R. Stein, Bryan D. Griffin, Kevin Tierney, Anders Leung, Angela Sloan, Darwyn Kobasa, Guillaume Poliquin, Gary P. Kobinger, David Safronetz   +9 more
doaj   +1 more source

Behavioral restriction, lorazepam, and escitalopram uniquely influence the expression of naturalistic stereotypy in deer mice: perspectives on anxiety- and compulsive-like behavior

Frontiers in Behavioral Neuroscience, 2022
Introduction: Stereotypical expression in laboratory-housed rodents can be explained by different motivational, coping, and motor dysfunction theories.
Johann T. Burke, Daniel C. Mograbi, Daniel C. Mograbi, De Wet Wolmarans   +3 more
doaj   +1 more source

Lyme Disease Agent Reservoirs Peromyscus leucopus and P. maniculatus Have Natively Inactivated Genes for the High-Affinity Immunoglobulin Gamma Fc Receptor I (CD64)

Pathogens, 2023
The abundant and widely distributed deermice Peromyscus leucopus and P. maniculatus are important reservoirs for several different zoonotic agents in North America.
Alan G. Barbour, Jonathan V. Duong, Anthony D. Long   +2 more
doaj   +1 more source

Community Assembly Reveals How Environmental Controls Over Rodent Competition Drive Deer Mouse Density and Hantavirus Infection [PDF]

Ecol Lett
We examined how community assembly processes shape Sin Nombre hantavirus (SNV) dynamics in rodent communities across the southwestern United States. Environmental factors structured community composition, which regulated deer mouse abundance and SNV infection, rather than diversity alone.
Luis A, Pearson D.
europepmc   +2 more sources

Interspecific variation in cooperative burrowing behavior by Peromyscus mice

Evolution Letters, 2022
Animals often adjust their behavior according to social context, but the capacity for such behavioral flexibility can vary among species. Here, we test for interspecific variation in behavioral flexibility by comparing burrowing behavior across three ...
Nicole L. Bedford, Jesse N. Weber, Wenfei Tong, Felix Baier, Ariana Kam, Rebecca A. Greenberg, Hopi E. Hoekstra   +6 more
doaj   +1 more source

High-elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta. [PDF]

J Physiol
Abstract figure legend We investigated how environmental hypoxia and genetic adaptation to high altitudes jointly impact the development of the placental exchange surface in ways that might protect fetal growth potential. We used wild‐derived, lab‐born North American deer mice (Peromyscus maniculatus) from low‐elevation and high‐elevation environments (
Wilsterman K, Cheviron ZA, Good JM, Gurnoe-Brantley K, Jewett KE, Kiel K, Larson AM.   +6 more
europepmc   +2 more sources