Results 51 to 60 of about 106,291 (299)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Altered Default Mode Network Dynamics in Civil Aviation Pilots

Frontiers in Neuroscience, 2020
BackgroundAirlines occupy an increasingly important place in the economy of many countries. Because air disasters may cause substantial losses, comprehensive surveys of the psychophysiological mechanism of flying are needed; however, relatively few ...
Xi Chen, Kaijun Xu, Yong Yang, Quanchuan Wang, Hao Jiang, Xiangmei Guo, Xipeng Chen, Jiazhong Yang, Cheng Luo   +8 more
doaj   +1 more source

Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls

Frontiers in Neuroimaging, 2023
Previous work in incarcerated boys and adult men and women suggest that individuals scoring high on psychopathic traits show altered resting-state limbic/paralimbic, and default mode functional network properties.
Corey H. Allen, J. Michael Maurer, Aparna R. Gullapalli, Bethany G. Edwards, Eyal Aharoni, Carla L. Harenski, Nathaniel E. Anderson, Keith A. Harenski, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Kent A. Kiehl, Kent A. Kiehl   +12 more
doaj   +1 more source

Aberrant default mode network homogeneity in patients with first-episode treatment-naive melancholic depression

, 2017
Background: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components.
Wang, Yi, Guo, Wenbin, Yang, Xin-hua, Cui, Xilong, Wang, Yefei, Gong, Jingbo, Tan, Changlian, Yang, Tian-xiao, Xie, Guangrong   +8 more
core   +1 more source

Parcellation‐based anatomic modeling of the default mode network

Brain and Behavior, 2021
Background The default mode network (DMN) is an important mediator of passive states of mind. Multiple cortical areas, such as the anterior cingulate cortex, posterior cingulate cortex, and lateral parietal lobe, have been linked in this processing ...
Zainab Sandhu, Onur Tanglay, Isabella M. Young, Robert G. Briggs, Michael Y. Bai, Micah L. Larsen, Andrew K. Conner, Vukshitha Dhanaraj, Yueh‐Hsin Lin, Jorge Hormovas, Rannulu Dineth Fonseka, Chad A. Glenn, Michael E. Sughrue   +12 more
doaj   +1 more source

Default mode network activity in bipolar disorder [PDF]

Epidemiology and Psychiatric Sciences, 2020
Abstract Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD).
Zovetti, Niccolò, Rossetti, Maria Gloria, Perlini, Cinzia, Maggioni, Eleonora, Bontempi, Pietro, Bellani, Marcella, Brambilla, Paolo   +6 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rapid plasticity of default-mode local network architectures following adult-onset blindness

Cell Reports
Summary: Sensory cortices are not silent in the absence of sensory inputs but generate spontaneous activity intrinsic to the cortical circuit referred to as default-mode activity.
Lukas Mesik, Katie Hang Thanh Pham, Keqin Ding, Yiyang Martin Huang, Daniel Severin, Alfredo Kirkwood, Andrei Dragomir, Nitish Thakor, Hey-Kyoung Lee   +8 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Viewing socio-affective stimuli increases connectivity within an extended default mode network

, 2017
Empathy is an essential ability for prosocial behavior. Previous imaging studies identified a number of brain regions implicated in affective and cognitive aspects of empathy.
Ye, Zheng, Goettlich, Martin, Rodriguez-Fornells, Antoni, Kraemer, Ulrike M., Muente, Thomas F.   +4 more
core   +1 more source