Results 71 to 80 of about 363,149 (303)

Rapid plasticity of default-mode local network architectures following adult-onset blindness

Cell Reports
Summary: Sensory cortices are not silent in the absence of sensory inputs but generate spontaneous activity intrinsic to the cortical circuit referred to as default-mode activity.
Lukas Mesik, Katie Hang Thanh Pham, Keqin Ding, Yiyang Martin Huang, Daniel Severin, Alfredo Kirkwood, Andrei Dragomir, Nitish Thakor, Hey-Kyoung Lee   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Deactivation of default mode network during touch [PDF]

Scientific Reports, 2019
AbstractInterpersonal touch possesses a strong affective component, which immediately evokes attention. The neural processing of such touch is moderated by specialized C-tactile nerve fibers in the periphery and results in central activation of somatosensory areas as well as regions involved in social processing, such as the superior temporal gyrus ...
Strauss, Timmy, Kämpe, Robin, Hamilton, Paul, Olausson, Håkan, Rottstaedt, Fabian, Raue, Claudia, Croy, Ilona   +6 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Default mode, dorsal attention and auditory resting state networks exhibit differential functional connectivity in tinnitus and hearing loss.

PLoS ONE, 2013
We investigated auditory, dorsal attention, and default mode networks in adults with tinnitus and hearing loss in a resting state functional connectivity study.
Sara A Schmidt, Kwaku Akrofi, Jake R Carpenter-Thompson, Fatima T Husain   +3 more
doaj   +1 more source

Attention and Default Mode Network Assessments of Meditation Experience during Active Cognition and Rest

Brain Sciences, 2021
Meditation experience has previously been shown to improve performance on behavioral assessments of attention, but the neural bases of this improvement are unknown.
Kathryn J. Devaney, Emily J. Levin, Vaibhav Tripathi, James P. Higgins, Sara W. Lazar, David C. Somers   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Altered Default Mode Network Dynamics in Civil Aviation Pilots

Frontiers in Neuroscience, 2020
BackgroundAirlines occupy an increasingly important place in the economy of many countries. Because air disasters may cause substantial losses, comprehensive surveys of the psychophysiological mechanism of flying are needed; however, relatively few ...
Xi Chen, Kaijun Xu, Yong Yang, Quanchuan Wang, Hao Jiang, Xiangmei Guo, Xipeng Chen, Jiazhong Yang, Cheng Luo   +8 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Platelet serotonin transporter function predicts default-mode network activity. [PDF]

PLoS ONE, 2014
The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space.
Christian Scharinger, Ulrich Rabl, Christian H Kasess, Bernhard M Meyer, Tina Hofmaier, Kersten Diers, Lucie Bartova, Gerald Pail, Wolfgang Huf, Zeljko Uzelac, Beate Hartinger, Klaudius Kalcher, Thomas Perkmann, Helmuth Haslacher, Andreas Meyer-Lindenberg, Siegfried Kasper, Michael Freissmuth, Christian Windischberger, Matthäus Willeit, Rupert Lanzenberger, Harald Esterbauer, Burkhard Brocke, Ewald Moser, Harald H Sitte, Lukas Pezawas   +24 more
doaj   +1 more source