Results 61 to 70 of about 363,149 (303)

Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls

Frontiers in Neuroimaging, 2023
Previous work in incarcerated boys and adult men and women suggest that individuals scoring high on psychopathic traits show altered resting-state limbic/paralimbic, and default mode functional network properties.
Corey H. Allen, J. Michael Maurer, Aparna R. Gullapalli, Bethany G. Edwards, Eyal Aharoni, Carla L. Harenski, Nathaniel E. Anderson, Keith A. Harenski, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Kent A. Kiehl, Kent A. Kiehl   +12 more
doaj   +1 more source

The default mode network and the working memory network are not anti-correlated during all phases of a working memory task.

PLoS ONE, 2015
IntroductionThe default mode network and the working memory network are known to be anti-correlated during sustained cognitive processing, in a load-dependent manner.
Tommaso Piccoli, Giancarlo Valente, David E J Linden, Marta Re, Fabrizio Esposito, Alexander T Sack, Francesco Di Salle   +6 more
doaj   +1 more source

Parcellation‐based anatomic modeling of the default mode network

Brain and Behavior, 2021
Background The default mode network (DMN) is an important mediator of passive states of mind. Multiple cortical areas, such as the anterior cingulate cortex, posterior cingulate cortex, and lateral parietal lobe, have been linked in this processing ...
Zainab Sandhu, Onur Tanglay, Isabella M. Young, Robert G. Briggs, Michael Y. Bai, Micah L. Larsen, Andrew K. Conner, Vukshitha Dhanaraj, Yueh‐Hsin Lin, Jorge Hormovas, Rannulu Dineth Fonseka, Chad A. Glenn, Michael E. Sughrue   +12 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Early detection of dementia with default-mode network effective connectivity

Nature Mental Health
Altered functional connectivity precedes structural brain changes and symptoms in dementia. Alzheimer’s disease is the largest contributor to dementia at the population level, and disrupts functional connectivity in the brain’s default-mode network (DMN).
Sam Ereira, S. Waters, Adeel Razi, Charles R. Marshall   +3 more
semanticscholar   +1 more source

Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals

Brain Communications, 2021
Cortical accumulation of amyloid beta is one of the first events of Alzheimer’s disease pathophysiology, and has been suggested to follow a consistent spatiotemporal ordering, starting in the posterior cingulate cortex, precuneus and medio-orbitofrontal ...
S. Ingala, Jori Tomassen, L. Collij, N. Prent, D. van ‘t Ent, M. ten Kate, E. Konijnenberg, M. Yaqub, P. Scheltens, E. D. de Geus, C. Teunissen, B. Tijms, A. Wink, F. Barkhof, B. V. van Berckel, P. Visser, Anouk den Braber   +16 more
semanticscholar   +1 more source

Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function. [PDF]

PLoS ONE, 2013
Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia.
Matthijs G Bossong, J Martijn Jansma, Hendrika H van Hell, Gerry Jager, René S Kahn, Nick F Ramsey   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Default mode network activity in bipolar disorder [PDF]

Epidemiology and Psychiatric Sciences, 2020
Abstract Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD).
Zovetti, Niccolò, Rossetti, Maria Gloria, Perlini, Cinzia, Maggioni, Eleonora, Bontempi, Pietro, Bellani, Marcella, Brambilla, Paolo   +6 more
openaire   +4 more sources