Results 61 to 70 of about 106,291 (299)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Default mode, dorsal attention and auditory resting state networks exhibit differential functional connectivity in tinnitus and hearing loss.

PLoS ONE, 2013
We investigated auditory, dorsal attention, and default mode networks in adults with tinnitus and hearing loss in a resting state functional connectivity study.
Sara A Schmidt, Kwaku Akrofi, Jake R Carpenter-Thompson, Fatima T Husain   +3 more
doaj   +1 more source

Attention and Default Mode Network Assessments of Meditation Experience during Active Cognition and Rest

Brain Sciences, 2021
Meditation experience has previously been shown to improve performance on behavioral assessments of attention, but the neural bases of this improvement are unknown.
Kathryn J. Devaney, Emily J. Levin, Vaibhav Tripathi, James P. Higgins, Sara W. Lazar, David C. Somers   +5 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Local and global measures: Default Mode Network.

, 2020
Local and global measures: Default Mode Network.
Carlo A. Marzi (8232450), Giorgia Parisi (8232444), Joan Guàrdia-Olmos (4068004), Caterina A. Pedersini (8232435), Nicolò Cardobi (8232441), Javier Sanchez-Lopez (534152), Marc Montalà-Flaquer (8232438), Silvia Savazzi (8232447)   +7 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Lifespan differences in background functional connectivity of core cognitive large-scale brain networks

Neuroscience Research
Large-scale brain networks undergo functional reorganization over the course of the lifespan, with concurrent implications for cognition. Characterizing network connectivity during a task may provide complementary insight into cognitive development and ...
Patrick J. Pruitt, Lingfei Tang, Jessica M. Hayes, Noa Ofen, Jessica S. Damoiseaux   +4 more
doaj   +1 more source

Platelet serotonin transporter function predicts default-mode network activity. [PDF]

PLoS ONE, 2014
The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space.
Christian Scharinger, Ulrich Rabl, Christian H Kasess, Bernhard M Meyer, Tina Hofmaier, Kersten Diers, Lucie Bartova, Gerald Pail, Wolfgang Huf, Zeljko Uzelac, Beate Hartinger, Klaudius Kalcher, Thomas Perkmann, Helmuth Haslacher, Andreas Meyer-Lindenberg, Siegfried Kasper, Michael Freissmuth, Christian Windischberger, Matthäus Willeit, Rupert Lanzenberger, Harald Esterbauer, Burkhard Brocke, Ewald Moser, Harald H Sitte, Lukas Pezawas   +24 more
doaj   +1 more source

Reduced coupling between offline neural replay events and default mode network activation in schizophrenia [PDF]

, 2023
Schizophrenia is characterized by an abnormal resting state and default mode network brain activity. However, despite intense study, the mechanisms linking default mode network dynamics to neural computation remain elusive.
Higgins, Cameron, Dolan, Raymond J, Nour, Matthew M, Woolrich, Mark W, Liu, Yunzhe   +4 more
core  

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source