Results 71 to 80 of about 716,083 (340)

Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function. [PDF]

PLoS ONE, 2013
Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia.
Matthijs G Bossong, J Martijn Jansma, Hendrika H van Hell, Gerry Jager, René S Kahn, Nick F Ramsey   +5 more
doaj   +1 more source

Dynamic subcortical modulators of human default mode network function

bioRxiv, 2021
The brain’s ‘default mode network’ (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although may involve key subcortical mechanisms, including hypothesized ...
B. Harrison, C. Davey, Hannah S. Savage, A. Jamieson, C. A. Leonards, B. Moffat, Rebecca K. Glarin, T. Steward   +7 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Rapid plasticity of default-mode local network architectures following adult-onset blindness

Cell Reports
Summary: Sensory cortices are not silent in the absence of sensory inputs but generate spontaneous activity intrinsic to the cortical circuit referred to as default-mode activity.
Lukas Mesik, Katie Hang Thanh Pham, Keqin Ding, Yiyang Martin Huang, Daniel Severin, Alfredo Kirkwood, Andrei Dragomir, Nitish Thakor, Hey-Kyoung Lee   +8 more
doaj   +1 more source

Distant from input : Evidence of regions within the default mode network supporting perceptually-decoupled and conceptually-guided cognition [PDF]

, 2018
The default mode network supports a variety of mental operations such as semantic processing, episodic memory retrieval, mental time travel and mind-wandering, yet the commonalities between these functions remains unclear.
Anderson, Behzadi, Benedek, Binder, Binder, Binder, Bonner, Bonnici, Bozeat, Buckner, Cabeza, Charlotte Murphy, Daniel S. Margulies, Davey, Davey, de Caso, Eklund, Elizabeth Jefferies, Engen, Gardner, Golchert, Gusnard, Hao-ting Wang, Humphreys, Humphreys, Jackson, Jefferies, Jenkinson, Jonathan Smallwood, Konishi, Krieger-Redwood, Leech, Leech, Margulies, Mesulam, Mladen Sormaz, Moscovitch, Murphy, Murphy, Patterson, Poerio, Price, Ralph, Rugg, Schacter, Schooler, Schwartz, Seghier, Shirley-Ann Rueschemeyer, Smallwood, Smallwood, Smith, Spreng, Spreng, Spreng, Spreng, Thompson, Vatansever, Visser, Visser, Visser, Wagner, Yeo, Zhang   +63 more
core   +5 more sources

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

Communications Biology, 2019
The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach.
P. Alves, C. Foulon, V. Karolis, D. Bzdok, D. Margulies, E. Volle, M. Thiebaut de Schotten   +6 more
semanticscholar   +1 more source

Dark control: The default mode network as a reinforcement learning agent

Human Brain Mapping, 2020
The default mode network (DMN) is believed to subserve the baseline mental activity in humans. Its higher energy consumption compared to other brain networks and its intimate coupling with conscious awareness are both pointing to an unknown overarching ...
Elvis Dohmatob, G. Dumas, D. Bzdok
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

An fMRI investigation of the relationship between future imagination and cognitive flexibility [PDF]

, 2017
While future imagination is largely considered to be a cognitive process grounded in default mode network activity, studies have shown that future imagination recruits regions in both default mode and frontoparietal control networks.
Abraham, Addis, Addis, Addis, Addis, Addis, Addis, Addis, Addis, Addis, Addis, Andelman, Andrews-Hanna, Axmacher, Bastin, Beaty, Beaty, Beaty, Beaty, Bellana, Benedek, Benedek, Benoit, Binder, Binder, Bonner, Buckner, Burianova, Burianova, C.L. Grady, Cauda, Chen, Christoff, Clark, Cole, D.L. Schacter, D.R. Addis, Dale, Damasio, Desikan, Dietrich, Dubois, Duff, Duval, Eckert, Eichenbaum, Ellamil, Eslinger, Fonov, Gaesser, Geisser, Gilbert, Gilbert, Gilhooly, Gilmore, Graham, Green, Guilford, Hannula, Hannula, Hassabis, Hirshhorn, Hutton, Irish, Irish, K. Wiebels, Klein, Kosillo, Kwan, Lambon Ralph, Lambon Ralph, Linden, Mace, Madore, Madore, Madore, Martin, McClelland, McIntosh, Menon, Meyer, Niendam, Norman, Oldfield, Price, R.L. Sumner, R.P. Roberts, Race, Rissman, Roberts, Rothermich, Rubin, Schacter, Schacter, Schacter, Schacter, Schacter, Seghier, Spreng, Spreng, Späti, Squire, Squire, Sridharan, Staresina, Suddendorf, Szpunar, Szpunar, Takeuchi, Taylor, Tomer, Tregellas, Uddin, V. van Mulukom, van der Heiden, van Mulukom, van Mulukom, van Veen, Viard, Viard, Wakusawa, Weiler, Wendelken, Wendelken, Wendelken, Westphal, Yeo   +126 more
core   +1 more source

The sense of self in the aftermath of trauma: lessons from the default mode network in posttraumatic stress disorder

European Journal of Psychotraumatology, 2020
Trauma can profoundly affect the sense of self, where both cognitive and somatic disturbances to the sense of self are reported clinically by individuals with posttraumatic stress disorder (PTSD).
R. Lanius, Braeden A. Terpou, M. McKinnon   +2 more
semanticscholar   +1 more source