Results 141 to 150 of about 736,428 (286)

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Macro stress testing with a macroeconomic credit risk model: Application to the French manufacturing sector. [PDF]

The aim of this paper is to build and estimate a macroeconomic model of credit risk for the French manufacturing sector. This model is based on Wilson's CreditPortfolioView model (1997a, 1997b); it enables us to simulate loss distributions for a credit ...
Avouyi-Dovi, S., Bardos, M., Jardet, C., Kendaoui, L., Moquet , J.   +4 more
core  

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Reducing Profit‐Seeking Default Behaviors in Demand Response via a Deep Learning‐Based Credit Scoring System

Engineering Reports
The participation of distributed energy resources in demand response enriches the manners of power grid dispatching. However, due to the profit‐seeking behaviors of some demand response suppliers, the cleared trading volumes may not be executed as ...
Ge Liu
doaj   +1 more source

Exploratory Graphics of a Financial Dataset [PDF]

company rating, default probability, support vector machines, colour ...
Antony Unwin, Martin Theus, Wolfgang Härdle   +2 more
core  

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

UniMR: A Plug‐and‐Play Framework of Automated Molecular Recognition for Scanning Tunneling Microscopy

Advanced Science, EarlyView.
UniMR, a training‐free framework for automated molecular recognition in STM images. By integrating adaptive feature selection with CLIP embeddings and Gaussian Mixture Modeling, UniMR achieves robust performance across diverse molecular systems and low‐resolution conditions.
Ziqiang Cao, Lingyin Zhang, Bingzheng Wu, Haonan Chen, Junhao Sun, Linghao Yan, Wenfei Li, Yangyang Wu, Zhifang Wang, Qigang Zhong, Lifeng Chi   +10 more
wiley   +1 more source

Assessing Credit with Equity: A CEV Model with Jump to Default [PDF]

Unlike in structural and reduced-form models, we use equity as a liquid and observable primitive to analytically value corporate bonds and credit default swaps. Restrictive assumptions on the firmâs capital structure are avoided.
Luciano Campi, Sbuelz, Simon Polbennikov
core  

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

SMEs probability of default: the case of the hospitality sector

Tourism & Management Studies, 2015
In this paper we analyze a set of financial ratios from hospitality sector SMEs in order to ascertain which factors determine a greater probability of default.
Luís Pacheco
doaj