Results 41 to 50 of about 91,262 (247)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Behavioral SciencesSuicide stands as one of the leading causes of non-accidental death among adolescents and young adults. The Integrated Motivational–Volitional Model (IMV) of suicidal behavior identifies feelings of defeat and entrapment as pivotal factors in the complex
Ana Huertes-del Arco +4 more
doaj +1 more source
Higher-Order Defeat and Withholding Judgment
Ergo, An Open Access Journal of Philosophy, 2021 Defeat by higher-order evidence needs defending. Maria Lasonen-Aarnio argues powerfully for the conclusion that higher-order evidence does not have an unlimited capacity to defeat justification. While developing her main argument Lasonen-Aarnio poses two
Earl Conee
doaj +2 more sources
Why Scottish nationalists won’t see Article 50 ruling as a defeat [PDF]
, 2017 First paragraph: The UK Supreme Court ruling over the triggering of Article 50, the EU process that will make Brexit possible, was half a victory for the Scottish government – and perhaps more than that. Access this article on The ...
Lynch, Peter
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2018 After arguing that infallibilism faces serious problems, this chapter turns to consider objections levelled at fallibilism. Chapters 5 and 6 consider the objection that fallibilism undermines closure for knowledge. In reply, it’s been argued that closure
Jessica Brown
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Brain, Behavior, & Immunity - Health, 2022 Myriad findings connect stress and inflammation to mood disorders. Social defeat in mice promotes the convergence of neuronal, central inflammatory (microglia), and peripheral immune (monocytes) pathways causing anxiety, social avoidance, and “stress ...
Damon J. DiSabato +9 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Pallas, 2019 To hide the defeat against the Etruscan king Porsenna in 508 BC, Roman historians used a narrative based on transposed Greek historiographical elements and the recorded actions of an anonymous pontiff on the pons Sublicius.
Alexis Mészáros
doaj +1 more source