Results 51 to 60 of about 91,262 (247)
BMC Public Health, 2023 Objectives This study explores whether feelings of defeat (i.e., a sense of failed struggle and losing rank; referred to as defeat for simplicity) mediated the effect of work stress on depression/anxiety, the effect of interpersonal needs on depression ...
Rongxi Wang +20 more
doaj +1 more source
About a defeat of the Centaurs, and how to imagine such an event in Olympia
, 2019 This posting, written 2019.04.19, picks up from where I left off in Classical Inquiries 2019.03.22, rewritten 2019.04.17. In the last paragraph of that posting, I focused on a myth that told about a defeat of the Centaurs, beastly hominoids who were half
Nagy, Gregory
core +4 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Frontiers in Psychology, 2019 BackgroundTransgender women sex workers have a high prevalence of depression. Low self-esteem and subsequent involuntary subordination (characterized by feelings of defeat and entrapment) are well-documented risk factors for depression. The object of the
Ruijie Chang +10 more
doaj +1 more source
Anhedonia in the shadow of chronic social defeat stress, or When the experimental context matters [PDF]
, 2008 One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events,
Dmitry A. Smagin +4 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
United States Counterterrorism on ISIS
Jurnal Studi Pemerintahan, 2016 The U.S. counter terrorism on ISIS had implemented with various strategies including degrading ISIS’s capability, shaping global coalition to defeat ISIS, and using trained military armed men for Iraq army forces, Kurdi army, Arabian army, and moderate ...
ANTON MINARDI
doaj
تحقیقات سلامت در جامعه, 2021 Introduction and purpose: Infertility is a multifaceted problem that can cause major disorders with emotional, social, and psychological consequences, such as reduced quality of marital relationship. Therefore, this study aimed to investigate the role of
Seyedeh Mohadeseh Rezaei +3 more
doaj
, 2021 Epistemic defeat is standardly understood in either evidentialist or responsibilist terms. The seminal treatment of defeat is an evidentialist one, due to John Pollock, who famously distinguishes between undercutting and rebutting defeaters.
Jack C. Lyons +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source