Results 81 to 90 of about 694,171 (324)

The Theories of war in practice: possible outcomes and means for the termination of war. Case study: Russian war against Ukraine

Social Development & Security
Purpose: is to anticipate the termination of the Russia-Ukraine war considering the underlying causes on the basis of main war termination theories. Method: comparative analysis, and synthesis.
Khayal Iskandarov, Piotr Gawliczek, Vagif Dadashzade   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A meta-analysis of perceptions of defeat and entrapment in depression, anxiety problems, posttraumatic stress disorder, and suicidality [PDF]

, 2015
This document is the Accepted Manuscript version of the following article: Andy P. Siddaway, Peter J. Taylor, Alex M. Wood, and Joerg Schulz, ‘A meta-analysis of perceptions of defeat and entrapment in depression, anxiety problems, posttraumatic stress ...
Abramowitz, Alex M. Wood, Allan, Andy P. Siddaway, Baumeister, Beck, Beck, Birchwood, Birchwood, Birchwood, Borenstein, Carvalho, Cheung, Clare, Cohen, Dixon, Dixon, Dunmore, Dunmore, Dunmore, Ehlers, Field, Garcia-Campayo, Gilbert, Gilbert, Gilbert, Gilbert, Gilbert, Gilbert, Gilbert, Goldstein, Griffiths, Gumley, Hedges, Higgins, Hunter, Iqbal, Jobson, Joerg Schulz, Karatzias, Kessler, Kessler, Kraemer, Martin, Moher, Nettle, Nock, Nolen-Hoeksema, Overton, O’Connor, O’Connor, Panagioti, Park, Peter J. Taylor, Price, Rasmussen, Rohde, Sloman, Sloman, Sloman, Sloman, Sterne, Stommel, Sturman, Sturman, Tang, Tang, Taylor, Taylor, Taylor, Taylor, Trachsel, Trickey, Troop, Troop, Troop, Vevea, White, Williams, Willner, Wyatt, Yoon   +81 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Passion to Fly and to the Courage to Lead: The Saga of Amelia Earhart – Leading Women into Flight [PDF]

, 2019
Truly a 20th Century leader, Amelia Earhart’s success was not only in breaking aviation records, but overcoming barriers for women. She set an example of courage, achievement, and not being afraid of envy, criticism, ignorance and indifference.
Iodice, Emilio F
core   +1 more source

Learning Lessons from the Populist Defeats: From Negative to Positive Constitutionalism

, 2023
Anna Śledzińska-Simon
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

About Defeat [PDF]

, 2014
There they lay, slung back in a corner, discarded from any future use, and looking as if every ounce of strength and good will had been wrung from their very soles.
Ebeling, Jean
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source