Results 101 to 110 of about 1,895,832 (295)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The diagnostic accuracy of preimplantation genetic testing (PGT) in assessing the genetic status of embryos: a systematic review and meta-analysis

Reproductive Biology and Endocrinology
Background Preimplantation genetic testing (PGT) is widely used in assisted reproduction to assess the genetic status of embryos. However, increasing evidence suggests that the trophectoderm (TE) may not fully reflect the genetic status of the inner cell
Kexin Chen, Zhixin Hu, Yuxuan Lian, Youzhen Han, Xiaoting Zhou, Yonggang Li, Lifeng Xiang, Weiqun Jiang, Mingying Li, Peng Zeng, Manqin Zhang, Xi Luo, Yongfang Xu, Haishan Zheng, Mei Tian, Mei Wang, Rui Ma, Jichun Yang, Yun Bai, Ruiyu Du, Bo Deng, Ze Wu, Yunxiu Li, Jiacong Yan   +23 more
doaj   +1 more source

Neonatal and maternal adverse outcomes among low-risk nulliparous women compared with multiparous women at 37–41 weeks of gestation: a cohort study in South China

Frontiers in Medicine
ObjectiveThe objective of this study was to compare the differences in neonatal and maternal adverse outcomes between low-risk full-term nulliparous (women giving birth for the first time) and low-risk full-term multiparous (women who have given birth ...
Yiping Liu, Bo Li, Jie Liu, Bin Wen, Chuan Xiao, Yaru Chen, Fanjuan Kong   +6 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identification of novel compound heterozygote variants in the PCCB gene in a fetus with undetectable fetal phenotype

BMC Medical Genomics
Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by functional deficiency of propionyl-CoA carboxylase, clinically characterized by life-threatening ketoacidosis, hyperammonemia, and multiorgan dysfunction.
Xingyu Feng, Yao Hu, Huiming Yan, Lin Zhou, Na Ma, Chulong Xiong, Hui Xi   +6 more
doaj   +1 more source

The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome

Endocrine Connections
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women’s reproductive capabilities and metabolic health, leading to a range of complications that can affect their quality of life.
Xuejun Yan, Dan Ma, Rongnian Li, Jing Xu, Ying Zou, Minmin He   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source