Results 131 to 140 of about 1,080,409 (319)

Defect-Induced Fluorescence of Silica Nanoparticles for Bioimaging Applications

, 2018
With biocompatibility, biodegradability, and high functionality, silica nanoparticles (SNPs) have been widely investigated for various biomedical applications.
Seulgi Han (6079166), Wonchan Park, Taehyung Lee, Sei Kwang Hahn (1423795), Woosung Kwon, Yoonsang Park (6079172), Jounghyun Yoo (4512652), Heemin Chang, Woosung Kwon (1835785), Wonchan Park (6079169), Heemin Chang (6079175), Sei Kwang Hahn, Seulgi Han, Jounghyun Yoo, Yoonsang Park, Taehyung Lee (106503)   +15 more
core   +1 more source

TRAPT: a multi-stage fused deep learning framework for predicting transcriptional regulators based on large-scale epigenomic data

Nature Communications
It is challenging to identify regulatory transcriptional regulators (TRs), which control gene expression via regulatory elements and epigenomic signals, in context-specific studies on the onset and progression of diseases.
Guorui Zhang, Chao Song, Mingxue Yin, Liyuan Liu, Yuexin Zhang, Ye Li, Jianing Zhang, Maozu Guo, Chunquan Li   +8 more
doaj   +1 more source

Defect formation from defect--anti-defect annihilations

, 2012
We show that when a topological defect with extended world-volume annihilates with an anti-defect, there arise topological defects with dimensions less than those of the original defects by one. Domain wall annihilations create vortices while monopole-string annihilations result in instantons.
openaire   +2 more sources

Transdimensional defects

Journal of High Energy Physics
Abstract This note introduces a novel paradigm for conformal defects with continuously adjustable dimensions. Just as the standard ε expansion interpolates between integer spacetime dimensions, a new parameter, δ, is used to interpolate between different integer-dimensional defects.
Elia de Sabbata, Nadav Drukker, Andreas Stergiou   +2 more
openaire   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Correlation between viral infections in male semen and infertility: a literature review

Virology Journal
Infertility affects approximately one-sixth of couples globally, with the incidence of male infertility steadily increasing. However, our understanding of the impact of viral infections on fertility remains limited. This review consolidates findings from
Yan Guo, Yunhua Dong, Runzi Zheng, Jiacong Yan, Weiyuan Li, Ya Xu, Xuelan Yan, Yunmei Ke, Yantao Li, Lifeng Xiang   +9 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source