Results 51 to 60 of about 1,902,450 (297)
The maternal drug exposure birth cohort (DEBC) in China
Nature CommunicationsDrug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy ...
Lu Li +17 more
doaj +1 more source
Frontiers in PharmacologyBackground: Aidi injection, a classic traditional Chinese medicine (TCM) formula, has been used on a broader scale in treating a variety of cancers. In this study, we aimed to explore the potential anti-tumor effects of Aidi injection in the treatment of
Shuyang Dai +14 more
doaj +1 more source
Defect modes of a Bose-Einstein condensate in an optical lattice with a localized impurity
, 2006 We study defect modes of a Bose-Einstein condensate in an optical lattice with a localized defect within the framework of the one-dimensional Gross-Pitaevskii equation.
A. I. Anselm +4 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
BMC MedicineBackground The development of the human vermiform appendix at the cellular level, as well as its function, is not well understood. Appendicitis in preschool children, although uncommon, is associated with a high perforation rate and increased morbidity ...
Lingdu Meng +14 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Aims: Cholangitis in biliary atresia (BA), which accelerates liver fibrosis progression, is among the most common serious complications after Kasai surgery; however, its etiology remains elusive.
Lingdu Meng +9 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
BMC Pregnancy and ChildbirthBackground The impact of vitamin D on spontaneous preterm birth (SPTB) is still not well understood. This study aimed to explore the relationship between maternal vitamin D receptor (VDR) and vitamin D-binding protein (VDBP) gene polymorphisms, as well ...
Nana Li +9 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Hepatology Communications, 2023 Whether N6-methyladenosine (m6A) is involved in biliary atresia (BA) remains undefined. Herein, we comprehensively evaluated the m6A profile in BA. When compared with normal controls, BA had an elevated m6A level with upregulated m6A writers.
Junfeng Wang +10 more
doaj +1 more source