Results 71 to 80 of about 1,080,409 (319)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Defect-activated versus intrinsic Raman spectra of GdN and LuN

, 2023
We report Raman studies of GdN and LuN, two of the rare-earth mononitrides that form a series of mostly intrinsic ferromagnetic semiconductors. Their rock-salt structure supports no first-order Raman scattering, but, nonetheless, we find a density-of ...
Benjamin Ruck (8509461), K Van Koughnet (17698506), William Holmes-Hewett (8512113), Harry Trodahl (8510619)   +3 more
core   +1 more source

The maternal drug exposure birth cohort (DEBC) in China

Nature Communications
Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy ...
Lu Li, Ke Wang, Meixian Wang, Jing Tao, Xiaohong Li, Zhen Liu, Nana Li, Xiaoxia Qiu, Hongwei Wei, Yuan Lin, Yuan He, Ying Deng, Hong Kang, Yuting Li, Ping Yu, Yanping Wang, Jun Zhu, Hanmin Liu   +17 more
doaj   +1 more source

The potential mechanism of Aidi injection against neuroblastoma—an investigation based on network pharmacology analysis

Frontiers in Pharmacology
Background: Aidi injection, a classic traditional Chinese medicine (TCM) formula, has been used on a broader scale in treating a variety of cancers. In this study, we aimed to explore the potential anti-tumor effects of Aidi injection in the treatment of
Shuyang Dai, Yaoyao Gu, Yong Zhan, Jie Zhang, Lulu Xie, Yi Li, Yifei Lu, Ran Yang, Enqing Zhou, Deqian Chen, Songbin Liu, Shan Zheng, Zhaopeng Shi, Kuiran Dong, Rui Dong   +14 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children

BMC Medicine
Background The development of the human vermiform appendix at the cellular level, as well as its function, is not well understood. Appendicitis in preschool children, although uncommon, is associated with a high perforation rate and increased morbidity ...
Lingdu Meng, Yifan Yang, Shiwei He, Huifen Chen, Yong Zhan, Ran Yang, Zifeng Li, Jiajie Zhu, Jin Zhou, Yi Li, Lulu Xie, Gong Chen, Shan Zheng, Xiaoying Yao, Rui Dong   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Defect-Induced Ultrafast Nonadiabatic Electron–Hole Recombination Process in PtSe₂ Monolayer

, 2022
Defects are inevitable in two-dimensional materials due to the growth condition, which results in many unexpected changes in materials’ properties. Here, we have mainly discussed the nonradiative recombination dynamics of PtSe2 monolayer without/with ...
Hongfu Huang (14145939), Junhao Peng (14023337), Minru Wen (10871399), Zixuan Li (164510), Le Huang (332269), Fugen Wu (1876132), Huafeng Dong (1535266)   +6 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source