Results 101 to 110 of about 1,994,533 (253)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Comparative Analysis of Explainable AI Methods for Manufacturing Defect Prediction: A Mathematical Perspective

Mathematics
The increasing complexity of manufacturing processes demands accurate defect prediction and interpretable insights into the causes of quality issues. This study proposes a methodology integrating machine learning, clustering, and Explainable Artificial ...
Gabriel Marín Díaz
doaj   +1 more source

Dealing with noise in defect prediction

, 2011
Many software defect prediction models have been built using historical defect data obtained by mining software repositories (MSR). Recent studies have discovered that data so collected contain noises because current defect collection practices are based
Sunghun Kim, Rongxin Wu, Liang Gong, Hongyu Zhang, Kim, Sung Hun, Gong, Liang, Wu, Rongxin, Zhang, Hongyu   +7 more
core   +1 more source

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

Defect Prediction for Capacitive Equipment in Power System

Applied Sciences
As a core component of the smart grid, capacitive equipment plays a critical role in modern power systems. When defects occur, they pose a significant threat to the safety of both other equipment and personnel.
Qingjun Peng, Zezhong Zheng, Hao Hu
doaj   +1 more source

Defect prediction for Cascading Style Sheets

, 2016
Testing is a crucial activity in software development. However exhaustive testing of a given software is impossible in practice because projects have serious time and budget limitations. Therefore, software testing teams need guidance about which modules
Diri, Banu, Bıcer, Serdar
core   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Getting defect prediction into industrial practice : The ELFF tool [PDF]

, 2017
Defect prediction has been the subject of a great deal of research over the last two decades. Despite this research it is increasingly clear that defect prediction has not transferred into industrial practice. One of the reasons defect prediction remains
Bowes, David, Shippey, Thomas, Petric, Jean, Hall, Tracy, Counsell, Steve   +4 more
core   +2 more sources

Software defect prediction using learning to rank approach. [PDF]

Sci Rep, 2023
Nassif AB, Talib MA, Azzeh M, Alzaabi S, Khanfar R, Kharsa R, Angelis L.   +6 more
europepmc   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source