Results 91 to 100 of about 277,827 (338)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Artificial Intelligence in Software Testing: A Systematic Review of a Decade of Evolution and Taxonomy

open access: yesAlgorithms
Software testing is fundamental to ensuring the quality, reliability, and security of software systems. Over the past decade, artificial intelligence (AI) algorithms have been increasingly applied to automate testing processes, predict and detect defects,
Alex Escalante-Viteri, David Mauricio
doaj   +1 more source

Does chronology matter in JIT defect prediction? A Partial Replication Study [PDF]

open access: green, 2021
Hadi Jahanshahi   +3 more
openalex   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Is "Better Data" Better than "Better Data Miners"? (On the Benefits of Tuning SMOTE for Defect Prediction)

open access: yes, 2018
We report and fix an important systematic error in prior studies that ranked classifiers for software analytics. Those studies did not (a) assess classifiers on multiple criteria and they did not (b) study how variations in the data affect the results ...
Bennin Kwabena Ebo   +7 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky   +8 more
wiley   +1 more source

Interpretable Software Defect Prediction from Project Effort and Static Code Metrics

open access: yesComputers
Software defect prediction models enable test managers to predict defect-prone modules and assist with delivering quality products. A test manager would be willing to identify the attributes that can influence defect prediction and should be able to ...
Susmita Haldar, Luiz Fernando Capretz
doaj   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

An Empirical Study on the Effectiveness of Feature Selection for Cross-Project Defect Prediction

open access: yesIEEE Access, 2019
Software defect prediction has attracted much attention of researchers in software engineering. At present, feature selection approaches have been introduced into software defect prediction, which can improve the performance of traditional defect ...
Qiao Yu   +4 more
doaj   +1 more source

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