Results 71 to 80 of about 1,994,533 (253)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Highly-Sensitive and Frequency-Selective Imaging of Defects via Local Defect Resonance [PDF]
, 2014 In this paper, a consistent way to enhance acoustic, optical and thermal defect responses is suggested by using selective ultrasonic activation of defects based on the concept of local defect resonance (LDR).
Solodov Igor +2 more
core +1 more source
Graph-based ML JIT defect prediction pipeline.
, 2023 The increasing complexity of today’s software requires the contribution of thousands of developers. This complex collaboration structure makes developers more likely to introduce defect-prone changes that lead to software faults.
Jonathan Bryan (15285217) +1 more
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshuIn recent years, efforts to promote energy conservation have become more active, and there is an increasing demand for high-efficiency motor coils. The efficiency of permanent magnet motors is closely related to manufacturing engineering.
Masato NAGANO +6 more
doaj +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Predicting Object Communication Errors in Constructor Development
IEEE AccessAn important challenge in dynamic software development is to predict object formation run-time object communication errors in complex environments involving multiple and multi-level object inheritance. This paper proposes a technique for doing so.
Abdul Majid Soomro +4 more
doaj +1 more source
Micro interaction metrics for defect prediction [PDF]
, 2011 There is a common belief that developers'behavioral interaction patterns may affect software quality. However, widely used defect prediction metrics such as source code metrics, change churns, and the number of previous defects do not capture developers ...
Sunghun Kim +8 more
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source