Results 81 to 90 of about 277,827 (338)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Improving Defect Prediction Models by Combining Classifiers Predicting Different Defects

, 2018
Background: The software industry spends a lot of money on finding and fixing defects. It utilises software defect prediction models to identify code that is likely to be defective. Prediction models have, however, reached a performance bottleneck. Any improvements to prediction models would likely yield less defects-reducing costs for companies.
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Dynamic behavior analysis of copper wire for predicting defects in the winding process of a motor coil

Nihon Kikai Gakkai ronbunshu
In recent years, efforts to promote energy conservation have become more active, and there is an increasing demand for high-efficiency motor coils. The efficiency of permanent magnet motors is closely related to manufacturing engineering.
Masato NAGANO, Taichi HIROSAWA, Hidefumi WAKAMATSU, Yoshiharu IWATA, Hironori SUZUKI, Takumi NAKAUE, Takahiro TANAKA   +6 more
doaj   +1 more source

Few-Shot Learning Based Balanced Distribution Adaptation for Heterogeneous Defect Prediction

IEEE Access, 2020
Heterogeneous defect prediction (HDP) aims to predict the defect tendency of modules in one project using heterogeneous data collected from other projects.
Aili Wang, Yutong Zhang, Haibin Wu, Kaiyuan Jiang, Minhui Wang   +4 more
doaj   +1 more source

Ab initio mechanical response: internal friction and structure of divacancies in silicon

, 2004
This letter introduces ab initio study of the full activation-volume tensor of crystalline defects as a means to make contact with mechanical response experiments. We present a theoretical framework for prediction of the internal friction associated with
Arias, T. A., Roundy, D., Ustunel, H.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Predicting Object Communication Errors in Constructor Development

IEEE Access
An important challenge in dynamic software development is to predict object formation run-time object communication errors in complex environments involving multiple and multi-level object inheritance. This paper proposes a technique for doing so.
Abdul Majid Soomro, Awad Bin Naeem, Susama Bagchi, Babul Salam KSM Kader Ibrahim, Sanjoy Kumar Debnath   +4 more
doaj   +1 more source