Results 31 to 40 of about 2,909,995 (289)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Evaluation of The Implications of The European Union’s New Product Liability Directive Proposal No. 2022/0302

open access: yesİstanbul Hukuk Mecmuası
The Product Liability Directive (PLD) 85/374 has been a significant aspect of European Union law for almost four decades, introducing strict liability for damages arising from defective products.
Ayşe Arat, Elif Akıncı
doaj   +1 more source

Fire risk analysis of the mobile power pack based on the fuzzy synthetic evaluation model

open access: yes工程科学学报, 2016
Due to the present situation of frequent fire accidents caused by the mobile power pack,fire risk based on the energy transfer theory and the fuzzy synthetic evaluation model was analyzed in the paper.
HUANG Guo-zhong   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Emotion finds a way to users from designers: assessing product images to convey designer's emotion [PDF]

open access: yes, 2012
Along with a growing interest in emotional design and pleasurable products, it is necessary to understand how designers are able to maintain emotional impacts of their design solutions throughout the design process, and how these solutions can find a way
AOUSSAT, Améziane   +4 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Manufacturer Liability for Cybersecurity Defects in Digital Products [PDF]

open access: yesCollection Regional Law Review
The proliferation of new digital products on the internal market has evoked the need for a change in product liability rules, with focus on the perils connected with cybersecurity defects of digital products.
Maja Proso
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Development risks: Definition under European Union law and justification for implementation in Serbian law [PDF]

open access: yesZbornik Radova: Pravni Fakultet u Novom Sadu, 2018
This paper analyses one of the most important and current issues related to the liability of the defective product producer, given that this form of liability has gained importance as a result of the development of consumer rights, the emphasis being on ...
Sekulić Miloš B.
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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