Results 41 to 50 of about 173,492 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Cost-Effective Imperfect Production-Inventory System under Variable Production Rate and Remanufacturing

open access: yesMathematics, 2023
Several industries are facing many challenges in their production systems due to increasing customer demand. Customer demand is growing for products with innovative features that are flexible, good quality, and appealing.
Baishakhi Ganguly   +3 more
doaj   +1 more source

Manufacturer's civil liability for damages caused by defective pharmaceutical product. [PDF]

open access: yes, 2014
This master thesis analyses main aspects of manufacturer's civil liability for the damage caused by defective pharmaceutical product. Conditions of manufacturer's strict liability in chosen aspect were ulmost unanalyzed in legal doctrine of Lithuania ...
Puodžius, Jonas,
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Generalization of cut-in pre-crash scenarios for autonomous vehicles based on accident data

open access: yesScientific Reports
The utilization of high-risk test cases constitutes an effective approach to enhance the safety testing of autonomous vehicles (AVs) and enhance their efficiency.
Pingfei Li   +6 more
doaj   +1 more source

Optimizing Defective Product Distribution for Sustainability and Profitability in Manufacturing Model under Neutrosophic Environment [PDF]

open access: yesNeutrosophic Sets and Systems
This study investigates the challenges associated with defective product distribution in manufacturing industries, contributing to environmental degradation, resource wastage, and financial losses.
B. Priskilla   +2 more
doaj   +1 more source

Compensation for damage caused by defective product [PDF]

open access: yes, 2019
79 Summary This diploma thesis deals with selected aspects of product liability. The main aim of this thesis is to conduct critical analysis of aspects related to the concept of product and its defects.
Sedláček, Jakub
core  

Impacts of collaborative investment and inspection policies on the integrated inventory model with defective items [PDF]

open access: yes, 2013
For an imperfect production system, to reduce quality-related costs, a manager may consider investing capital in quality improvement. In general, the investment expense in reducing the defective rate of items is often paid by the vendor.
Ouyang, Liang-Yuh; Chen, Li-Yuan; Yang, Chih-Te   +1 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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