Results 41 to 50 of about 444,038 (301)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Chatter, Clatter, and Blinks: Defective Car Alerts and the Role of Technological Advances in Design Defect/failure to Warn Cases [PDF]

, 2010
Car owners are familiar with the warning lights on the dashboard and the beeping sound reminding them to use their seatbelt. But, neither the legislature nor courts have concretely defined the legal nature of these alerts. This iBrief will analyze when a
McKell, James Forrest, Jr.
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of the cause of the defect packaging of capsule products using six sigma: A case study (PT SM)

SHS Web of Conferences, 2018
This research aims to manage the amount of defective packaging of capsule products in the department of capsule product at PT SM. It is important because the number of defective packaging of capsule products is high and exceeds the limits of maximum, i.e.
Fidiyanti Finsaria, Susanto Novie
doaj   +1 more source

Hazardous Waits: CPSC Lets Crucial Time Pass Before Warning Public About Dangerous Products [PDF]

, 2008
Despite a law requiring manufacturers to provide the Consumer Product Safety Commission (CPSC) with "immediate" notification of dangerous products, the agency typically delays nearly seven months after learning of dangerous, defective products before ...
Taylor Lincoln
core  

Potential Errors and Test Assessment in Software Product Line Engineering

, 2015
Software product lines (SPL) are a method for the development of variant-rich software systems. Compared to non-variable systems, testing SPLs is extensive due to an increasingly amount of possible products.
Lackner, Hartmut, Schmidt, Martin
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

MODERN PRODUCT LIABILITY LAW JURIDICAL BASIS IN ISLAMIC LAW

Hamdard Islamicus, 2021
The term “Product liability” is used to identify the body of lawthat seeks to hold manufacturers and sellers financially responsiblefor their products not meeting safety standards.
MUHAMMAD AKBAR KHAN
doaj   +2 more sources

Liability of Marketplaces: A Comparative Analysis of Legal Approaches in the USA and France

Цифровое право
The article analyzes two opposing approaches to the liability of marketplaces for the sale of defective products in the U.S. and France. The purpose of the study is to compare these models of regulation and identify the peculiarities of the legal status ...
A. A. Onianova
doaj   +1 more source