Results 41 to 50 of about 502,268 (301)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effects of the Location of Dural Tear and Repair in the Development of Pneumocephalus after Spinal Surgery

Haseki Tıp Bülteni, 2019
Aim:To investigate the incidence of pneumocephalus related to location of iatrogenic dural defects and the role of dural defect repair in the development of pneumocephalus.Methods:In this prospective study, 18 patients, who underwent surgery for spinal ...
Ahmet Öğrenci
doaj   +1 more source

Cardiopulmonary bypass without the use of donor blood components in heart surgery in an 8-kg infant: case report

Патология кровообращения и кардиохирургия, 2018
The issue of rejecting donor blood components intraoperatively in children with congenital heart defects is widely discussed in the world literature. This is primarily due to the presence of a low volume of circulating blood, which leads to excessive ...
Artem A. Ivkin, Roman A. Kornelyuk, Dmitriy V. Borisenko, Andrey V. Nohrin, Dmitriy L. Shukevich   +4 more
doaj   +1 more source

Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana.

New England Journal of Medicine, 2019
BACKGROUND A preliminary safety signal for neural-tube defects was previously reported in association with dolutegravir exposure from the time of conception, which has affected choices of antiretroviral treatment (ART) for human immunodeficiency virus ...
Rebecca Zash, Lewis B Holmes, M. Diseko, D. Jacobson, S. Brummel, G. Mayondi, Arielle Isaacson, S. Davey, Judith Mabuta, M. Mmalane, T. Gaolathe, M. Essex, S. Lockman, J. Makhema, R. Shapiro   +14 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Exploratory clinical trial on the safety and capability of dMD-001 in lumbar disc herniation: Study protocol for a first-in-human pilot study

Contemporary Clinical Trials Communications, 2021
Herniated nucleus pulposus (NP), one of the most common diseases of the spine, is surgically treated by removing the sequestered NP. However, intervertebral disc (IVD) defects may remain after discectomy, leading to inadequate tissue healing and ...
Katsuhisa Yamada, Maeda Kenichiro, Yoichi M. Ito, Fujio Inage, Toshiyuki Isoe, Nozomi Yokota, Osamu Sugita, Norihiro Sato, Khin Khin Tha, Norimasa Iwasaki, Teruyo Arato, Hideki Sudo   +11 more
doaj   +1 more source

Deficiencies of the microelements, folate and vitamin B12 in women of the child bearing ages in Gorgan, Northern Iran [PDF]

, 2013
Background: The deficiencies of folic acid, vitamin B12, and microelements during pregnancy may affect the health of newborns. Objectives: To assess the serum levels of folate, vitamin B12, iron, zinc and copper in healthy women of the childbearing ages ...
Behnampour, N., Jafar Golalipour, M., Sedehi, M.   +2 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Ventilatory Defects in Toll Plaza Workers at Sriperumbudur Toll Plaza, Tamil Nadu, India [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Highways are the arteries of the nation. As fast as they grow, many toll plazas are installed to collect the taxes, ignoring the health hazards of the toll collectors due to the air pollution caused by the vehicular emissions.
VP Sundaravadivel, K Senthil Kumar, Varadharaju, Krishnapriya   +3 more
doaj   +1 more source

TSC2/PKD1 contiguous deletion syndrome in a pregnant woman: A case report

Frontiers in Medicine, 2023
TSC2/PKD1 contiguous gene deletion syndrome is a disease caused by the deletions of the TSC2 and PKD1 genes. This is a rare contiguous genomic disease with clinical manifestations of tuberous sclerosis and polycystic kidney disease.
Shaofang Huang, Kangxiang Xu, Yuqi Xu, Lu Zhao, Xiaoju He   +4 more
doaj   +1 more source