Results 91 to 100 of about 1,062,401 (295)
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Quality, experience, and monopoly : the Soviet market for weapons under Stalin [PDF]
Monopoly is a particular problem in markets where experience goods are traded, since the consumer cannot respond to bad experiences by switching repeat purchases to another supplier.
Harrison, Mark, Markevich, Andreĭ
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Masarykova obhajoba křesťanství
Studia Historica Brunensia, 2016 This paper examines Masaryk's central notions concerning the importance of religion in the life of individuals and societies. It also looks at Masaryk's view of the difference between the official dogmatic Christianity of the Catholic Church and early ...
Marie L. Neudorflová
doaj
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
ENERGY IN THE CONTEXT OF THE PRESENT CHALLENGES TO THE EUROPEAN COMMON SECURITY AND DEFENCE POLICY [PDF]
EURINT, 2014 The Common Security and Defence Policy is a part of the European Union’s Common Foreign and Security Policy (CFSP) and establishes the policy framework for the institutional structures and military instruments which have to deal with the security ...
Gabriel ANDRUSEAC, Liviu George MAHA
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Excavations at Cricklade, Wiltshire, 1975
Internet Archaeology, 2003 The town of Cricklade in Wiltshire, England is one of the most regular examples of the class of Saxon urban fortresses, created as part of a fort-system in the late 9th century, which are included in the Burghal Hidage List.
Jeremy Haslam
doaj +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
The Failing Firm Defence: Merger Policy and Entry [PDF]
This paper considers the `failing firm defence'. Under this principle, found in most antitrust jurisdictions, a merger that would otherwise be blocked due to its adverse effect on competition is permitted when the firm to be acquired is a failing firm ...
Helen Weeds, Mason, Robin
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