Results 51 to 60 of about 431,850 (303)
, 2023 Abstract. In his recent book The Value Gap (2021), Toni Rønnow-Rasmussen defends a pluralist view of final goodness and goodness-for, according to which neither concept is analysable in terms of the other. In this paper I defend a specific version of monism, namely so-called ‘Mooreanism’, according to which goodness-for is analysable partly in terms of
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Defence white paper 2015 public consultation document [PDF]
, 2015 The New Zealand Government has directed that a review of its defence policy be conducted over the course of 2015. The Government last updated its defence policy through the Defence White Paper 2010.
Ministry of Defence (NZ)
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Understanding and Exploiting Post-Translational Modifications for Plant Disease Resistance
Biomolecules, 2021 Plants are constantly threatened by pathogens, so have evolved complex defence signalling networks to overcome pathogen attacks. Post-translational modifications (PTMs) are fundamental to plant immunity, allowing rapid and dynamic responses at the ...
Catherine Gough, Ari Sadanandom
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Le Québec et les retombées économiques de la défense. Que reste-t-il ?
Revue Interventions Économiques, 2014 In Canada, as in most countries, the use of procurement contracts from the Department of Defence has become an instrument of economic development. All regions of Canada are seeking their share of the benefits associated with the defence sector, a process
Yves Bélanger, Marc-André Houle
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Journal for General Philosophy of Science, 2013 In this paper, we examine what is to be said in defence of Machamer, Darden and Craver’s (MDC) controversial dualism about activities and entities (Machamer, Darden and Craver’s in Philos Sci 67:1–25, 2000). We explain why we believe the notion of an activity to be a novel, valuable one, and set about clearing away some initial objections that can lead
Illari, P, Williamson, J
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Report on abuse at the Australian Defence Force Academy [PDF]
, 2014 This review assessed accounts of abuse at the Australian Defence Force Academy, and recommends a Royal Commission. Summary The Defence Abuse Response Taskforce (Taskforce) was established on 26 november 2012 as part of the Government’s response to the ...
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