Results 81 to 90 of about 1,062,401 (295)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Vietnam : une géopolitique en mutation au risque d’un dilemme stratégique ?
Moussons, 2019 The rivalry between People’s Republic of China and Vietnam over the South China Sea highlights the profound changes Vietnam has experienced in its regional ambitions and geopolitical perceptions. These have been and remain fundamentally structured by its
Laurent Gédéon
doaj +1 more source
On the Effective Design of the Efficiency Defence [PDF]
The efficiency defence was long delayed in the European merger control due to costly implementation issues. In this paper we argue that the upstream consequences of the efficiency defence should equally be considered, namely the improvement of the ...
Andreea Cosnita, Jean-Philippe Tropeano
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Crying poor? The affordability of defence expenditure [PDF]
The May budget saw deep cuts made to Australia\u27s defence budget over the next few years. It will be up to next year\u27s Defence White Paper to decide what happens after that.
Mark Thomson
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FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Prickly Defenders: A Review of Venomous Sea Urchins (Echinoidea)
Marine DrugsSea urchins, Echinoidea, are widely known for their defensive spines and pedicellariae, with some species having co-evolved venom in conjunction with those appendages. Despite this, their venomous arsenal remains poorly understood.
Sina Ehlert-Flaskämper +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
The Strategic Defence Review is an incoherent mess of stalled (but unresolved) decision making: it creates future problems that will not go away [PDF]
, 2011 This week’s review of Britain’s defence spending is the opening salvo of the coalition’s plans to review spending across government. David Cameron and George Osborne have walked a finely balanced line of compromise to appease the defence establishment ...
Brown, Chris
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