Results 31 to 40 of about 393,145 (302)

Effective Systems Engineering Training [PDF]

, 2007
The need for systems engineering training is steadily increasing, as both the defense and commercial markets take on more complex "systems of systems" work.
Hefner, Rick
core   +1 more source

SWOT Analysis And Analytical Hierarchy Process (AHP) To Determine A Sustainable Development Strategy In Indonesia's National Defense Industry

Jurnal Pamator, 2023
Improving national defense can be done by strengthening the national defense industry. A strong defense industry will produce modern and sophisticated military equipment according to user needs. The large number of military equipment imported from abroad
Ali Mashudi, Moeljadi Moeljadi, Herman S., Alfi Haris Wanto   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Justification of a set of measures for forming an institutional environment and a management system for defense industry complex diversification

Управление
The wave-like nature of the state defense order confirms the need to diversify the defense enterprises’ activities as a way to improve their sustainability and development, which allows them to maintain the required level of the country’s defense ...
D. Yu. Baydarov, D. Yu. Faikov
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ethylene supports colonization of plant roots by the mutualistic fungus Piriformospora indica [PDF]

, 2012
The mutualistic basidiomycete Piriformospora indica colonizes roots of mono- and dicotyledonous plants, and thereby improves plant health and yield. Given the capability of P.
A Leon-Reyes, A Sirrenberg, A Tsuchisaka, A Varma, A Zuccaro, AB Bleecker, Alexandra Molitor, AN Stepanova, B Adie, Behnam Khatabi, C Langebartels, Christian Lindermayr, CMJ Pieterse, CMJ Pieterse, D Tudela, DA Cartwright, Diter von Wettstein, E Sisler, E Stein, F Boutrot, F Boutrot, F Guinel, F Waller, G Felix, H Guo, HS Chae, HS Chae, I Camehl, JJ Kieber, Jörg Durner, K Ruzicka, K Tsuda, Karl-Heinz Kogel, KJ Bradford, KLC Wang, L Gómez Gómez, LC van Loon, LCW Kevin, M Berrocal Lobo, M Berrocal-Lobo, M Concepcion, M Tamaoki, MD Kendrick, Michael Polymenis, P Schäfer, P Schäfer, P Zimmermann, Patrick Schäfer, R Varma Penmetsa, RV Penmetsa, S Deshmukh, S Jacobs, S Mersmann, S Van der Ent, S Verma, SA Finlayson, SD Yoo, SM Brady, Stefanie Pfiffi, T Boller, T Peškan Berghöfer, T Riedel, TD Schmittgen, V Sundaresan, WF Broekaert, X Qiang, Y Liu   +66 more
core   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Skills Gap & Competitive Development: the problem of competitiveness balance in the “higher education–labor market” ecosystem

Університети і лідерство
The article is devoted to the systematic analysis of the skills gap phenomenon and its connection with competitive development on the example of the fields of activity requiring higher education.
Володимир Луговий, Олена Слюсаренко, Жаннета Таланова   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source