Results 61 to 70 of about 1,092,582 (286)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
On the Importance of Host MicroRNAs During Viral Infection
Frontiers in Genetics, 2018 Every living organism has to constantly face threats from the environment and deal with a large number of pathogens against which it has to defend itself to survive.
Erika Girardi +2 more
doaj +1 more source
Geometry-based Detection of Flash Worms [PDF]
, 2006 While it takes traditional internet worms hours to infect all the vulnerable hosts on the Internet, a flash worm takes seconds. Because of the rapid rate with which flash worms spread, the existing worm defense mechanisms cannot respond fast enough to ...
Kim, Sang Soo
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Characterization of peroxidase and catalase genes in defense mechanisms of Physcomitrella patens [PDF]
, 2019 Systemic acquired resistance (SAR) and the hypersensitive response (HR) are two important induced defense mechanisms in plants. SAR is the development of an enhanced resistance to a pathogen due to a prior encounter.
Ciulla, Lauren
core +1 more source
Mitigating Branch-Shadowing Attacks on Intel SGX using Control Flow Randomization
, 2018 Intel Software Guard Extensions (SGX) is a promising hardware-based technology for protecting sensitive computations from potentially compromised system software.
Brasser F. +4 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source