Results 91 to 100 of about 382,541 (286)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Forecasting the effects of reduced defense spending [PDF]

open access: yes
Forecasts from a vector autoregressive model indicate that the substantial cuts in defense spending proposed by the Bush Administration in 1991 are likely to reduce GNP in both the short run and the long run.
Christopher Otrok, Peter Ireland
core   +2 more sources

Defense Government Spending Is Contractionary, Civilian Government Spending Is Expansionary [PDF]

open access: yes, 2014
Impulse responses to government spending shocks in Standard Vector Autoregressions (SVARs) typically display "expansionary" features. However, SVARs can be subject to a "non-fundamentalness" problem. "Expectations - Augmented" VARs (EVARs), which use direct measures of forecasts of defense spending, typically display "contractionary" responses to a ...
openaire   +1 more source

Defense Spending, Natural Resources, and Conflict [PDF]

open access: yesDefence and Peace Economics, 2014
This special edition is the product of the 16th Annual International Conference on Economics and Security, held at the American University in Cairo, Egypt, 21–22 June 2012.
openaire   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

open access: yesAdvanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen   +10 more
wiley   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

open access: yesAdvanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen   +14 more
wiley   +1 more source

Estimating the Function of Demand for Defensive Expenditures in Iran [PDF]

open access: yesعلوم و فنون نظامی, 2016
Defensive Expenditures in Iran is a significant part of the total public expenditures due to its lack of security in the Middle East and the security threats of some countries in the world.
abolghasem golkhandan
doaj  

AN ECONOMETRIC ANALYSIS OF THE EFFECTS OF AGGREGATE DEFENSE SPENDING ON AGGREGATE OUTPUT: THE CASE OF TURKEY, 1950-2002 [PDF]

open access: yes
This study utilizes the new macroeconomic theory and multivariate cointegration analysis in search of the effects of aggregate defense spending on aggregate output in Turkey. This study provides the empirical evidence that there is a strong positive long-
Halicioglu Ferda
core  

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang   +16 more
wiley   +1 more source

Inefficiency in Legislative Policy-Making: A Dynamic Analysis [PDF]

open access: yes
This paper develops an infinite horizon model of public spending and taxation in which policy decisions are determined by legislative bargaining. The policy space incorporates both productive and distributive public spending and distortionary taxation ...
Battaglini, Marco, Coate, Stephen
core   +3 more sources

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