Whole blood RNA signatures in tuberculosis patients receiving H56:IC31 vaccine as adjunctive therapy [PDF]
Frontiers in ImmunologyIntroductionTherapeutic vaccination in tuberculosis (TB) represents a Host Directed Therapy strategy which enhances immune responses in order to improve clinical outcomes and shorten TB treatment.
Noelia Alonso-Rodríguez +11 more
doaj +5 more sources
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients [PDF]
Nature Communications, 2021 Modulating the host immune response during tuberculosis is an emerging and critical advance in the therapeutic approach. Here the authors present data from a first-in-human phase I/II randomised trial on the safety and immunogenicity of adjuvant therapy ...
Peter Bang +2 more
exaly +7 more sources
Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis [PDF]
PLoS ONE, 2016 The search for new and improved tuberculosis (TB) vaccines has focused on IFN-γ both for selecting antigens and for evaluating vaccine delivery strategies.
Peter Andersen +2 more
exaly +5 more sources
A phase 1b randomized study of the safety and immunological responses to vaccination with H4:IC31, H56:IC31, and BCG revaccination in Mycobacterium tuberculosis-uninfected adolescents in Cape Town, South Africa [PDF]
EClinicalMedicine, 2020 Background: Tuberculosis (TB) remains the leading cause of infectious disease-related death. Recently, a trial of BCG revaccination and vaccination with H4:IC31, a recombinant protein vaccine, in South African adolescents (Aeras C-040-404) showed ...
Andrew Fiore-Gartland +2 more
exaly +5 more sources
Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [PDF]
Frontiers in ImmunologyIntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways.
Ranmali Kavishna +9 more
doaj +2 more sources
Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone [PDF]
Frontiers in Immunology, 2020 Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and ...
Aneesh Thakur +6 more
doaj +5 more sources
Antigen surface display in two novel whole genome sequenced food grade strains, Lactiplantibacillus pentosus KW1 and KW2 [PDF]
Microbial Cell FactoriesBackground Utilization of commensal bacteria for delivery of medicinal proteins, such as vaccine antigens, is an emerging strategy. Here, we describe two novel food-grade strains of lactic acid bacteria, Lactiplantibacillus pentosus KW1 and KW2, as well ...
Kamilla Wiull +6 more
doaj +2 more sources
Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?
Vaccines, 2021 Characterizing the impact of the vaccination schedule on the induction of B and T cell immune responses is critical for improving vaccine immunogenicity.
Elena Pettini +4 more
doaj +1 more source
Dynamic Common Correlated Effects of Geopolitical Risk on International Tourism Arrivals
Folia Oeconomica Stetinensia, 2023 Geopolitical risk is currently recognized as a worldwide concern that significantly affects various economic sectors. As a consequence, rising geopolitical risks can cause a decline in the number of tourist arrivals.
Herman Suzana
doaj +1 more source
Frontiers in Immunology, 2018 The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting.
Annalisa Ciabattini +10 more
doaj +1 more source