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The recent advances in vaccine adjuvants [PDF]
Frontiers in ImmunologyVaccine adjuvants, as key components in enhancing vaccine immunogenicity, play a vital role in modern vaccinology. This review systematically examines the historical evolution and mechanisms of vaccine adjuvants, with particular emphasis on innovative ...
Ren Fang
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Medicine in Drug Discovery, 2021 Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity.
Zhenchuan Wu, Keqin Liu
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Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionVaccine adjuvants enhance immune responses by boosting vaccine efficacy, reducing required doses, and improving long-term immunity. The Vaxjo database is a web-based resource that stores information on vaccine adjuvants, including their names,
Joshua Monickaraj +13 more
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Licensed and investigational TLR4 agonists as vaccine adjuvants: structural basis, clinical progress, and future directions [PDF]
Frontiers in ImmunologyThe development of innovative vaccine platforms, including protein subunit and nucleic acid vaccines, has advanced rapidly and established new technical paradigms for infectious disease prophylaxis.
Jiasheng Zhou +30 more
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Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions [PDF]
Iranian Journal of Immunology, 2023 The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and provide protection against different kinds of infections.
Arslan Habib +10 more
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Research Progress of Aluminum Phosphate Adjuvants and Their Action Mechanisms
Pharmaceutics, 2023 Although hundreds of different adjuvants have been tried, aluminum-containing adjuvants are by far the most widely used currently. It is worth mentioning that although aluminum-containing adjuvants have been commonly applied in vaccine production, their ...
Ting Zhang +5 more
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Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity
Vaccines, 2021 Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li +3 more
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Current status and prospect for development of COVID-19 vaccine adjuvants
陆军军医大学学报, 2022 Vaccines are the most economical and effective means to protect against SARS-CoV-2 infection. Adjuvants are able to enhance antigen-specific immune responses, reduce antigen doses and vaccination times, and reshape adaptive immune responses, which are ...
LI Haibo, CHENG Hao
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Research progress in the development of natural-product-based mucosal vaccine adjuvants
Frontiers in Immunology, 2023 Mucosal vaccines have great potential and advantages in preventing infection caused by multiple pathogens. In developing mucosal vaccines, the biggest challenge comes from finding safe and effective adjuvants and drug delivery systems. Great progress has
Yingying Gao, Ying Guo
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Microorganisms, 2023 Microbial pesticides can be significantly improved by adjuvants. At present, microbial pesticide formulations are mainly wettable powders and suspension concentrations, which are usually produced with adjuvants such as surfactants, carriers, protective ...
Fuyong Lin +7 more
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