Results 31 to 40 of about 104,480 (297)

Rational Combination of Dominant and Subdominant Antigens with Nanoadjuvant Elicits Durable Immunity Against Staphylococcus aureus

Vaccines
Objectives: In response to the challenge that Staphylococcus aureus (S. aureus) vaccines fail to induce durable protective immunity, this study aims to develop a novel antigen-adjuvant co-design strategy.
Zhuoyue Shi, Jiayue Xi, Minxuan Cui, Zhuo Wan, Yufei Hou, Zhengjun Ma, Nan Sun, Yupu Zhu, Muqiong Li, Dong Wang, Xin He, Qian Yang, Chaojun Song, Li Fan   +13 more
doaj   +1 more source

The Effects of Adjuvants on the Wetting and Deposition of Insecticide Solutions on Hydrophobic Wheat Leaves

Agronomy, 2022
Pesticide droplet deposition determines the efficacy of pesticide solution and is a critical process in pesticide application. Adding spray adjuvants can improve droplet deposition to a certain extent, but there are currently many types of adjuvants with
Yuying Song, Qiliang Huang, Guizhen Huang, Mingxin Liu, Lidong Cao, Fengmin Li, Pengyue Zhao, Chong Cao   +7 more
doaj   +1 more source

Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against Staphylococcus aureus infection

Frontiers in Immunology
For decades, Staphylococcus aureus (S. aureus) vaccine development prioritized humoral immunity, heavily relying on recombinant protein antigens adjuvanted with aluminum (Alum), particularly in multivalent formulations.
Jiayue Xi, Jiayue Xi, Minxuan Cui, Minxuan Cui, Zhuoyue Shi, Zhuoyue Shi, Zhuo Wan, Yufei Hou, Yufei Hou, Nan Sun, Nan Sun, Muqiong Li, Muqiong Li, Zhengjun Ma, Zhengjun Ma, Yupu Zhu, Yupu Zhu, Xin He, Xin He, Qian Yang, Zhuojun Shi, Huifang Nie, Huifang Nie, Chaojun Song, Li Fan, Li Fan   +25 more
doaj   +1 more source

Immune mechanisms of influenza vaccine adjuvants and respiratory syncytial viral vaccines [PDF]

, 2017
Adjuvants have been used for enhancing vaccine-specific immune responses, but the mechanisms of adjuvants and the roles of CD4 in adjuvant effects have been poorly understood.
Ko, Eunju
core   +1 more source

Antigen-Dependent Adjuvanticity of Poly(lactic-co-glycolic acid)-polyethylene Glycol 25% Nanoparticles for Enhanced Vaccine Efficacy

Vaccines
Background: A key component in modern vaccine development is the adjuvant, which enhances and/or modulates the antigen-specific immune response. In recent years, nanoparticle (NP)-based adjuvants have attracted much research attention owing to their ...
Minxuan Cui, Jiayue Xi, Zhuoyue Shi, Yupu Zhu, Zhengjun Ma, Muqiong Li, Qian Yang, Chaojun Song, Li Fan   +8 more
doaj   +1 more source

Comparative Immunogenicity Evaluation of Characterized Chitosan-Based and Other Adjuvants for Inactivated Influenza Vaccines

Эпидемиология и вакцинопрофилактика, 2016
Chitosan-based adjuvants combine effectiveness, safety and economic feasibility and thus are quite promising for enhancement of influenza control via vaccination, however, problems of characterization and reproducibility remain unresolved; data on ...
L. M. Khantimirova, O. S. Kashirina, M. I. Chernikova, Y. M. Vasiliev   +3 more
doaj   +1 more source

General characteristics of adjuvants and their mechanisms of action (part 2)

Биопрепараты: Профилактика, диагностика, лечение, 2021
One of the major public health challenges today is development of new vaccines and technologies to optimize the vaccination process. There is a growing scientific interest in vaccine adjuvants that enhance vaccine immunogenicity.
N. А. Alpatova, Zh. I. Avdeeva, S. L. Lysikova, O. V. Golovinskaya, L. A. Gayderova, V. P. Bondarev   +5 more
doaj   +1 more source

Statins as adjuvants [PDF]

Nature Reviews Immunology, 2018
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire   +2 more sources

Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune Responses

Pharmaceutics, 2021
Discovery and development of novel adjuvants that can improve existing or next generation vaccine platforms have received considerable interest in recent years.
J. Timothy Prior, Christopher Davitt, Jonathan Kurtz, Patrick Gellings, James B. McLachlan, Lisa A. Morici   +5 more
doaj   +1 more source

Adjuvant synergy: the effects of nasal coadministration of adjuvants

, 2004
Modern peptide and protein subunit vaccines suffer from poor immunogenicity and require the use of adjuvants. However, none of the currently licensed adjuvants can elicit cell-mediated immunity or are suitable for mucosal immunization.
Alpar, H.O., Bramwell, V.W., Moschos, S.A., Somavarapu, S.   +3 more
core   +1 more source