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Current HIV Research, 2010 The vast majority of pathogens invade the body through or establish infections in the mucosal tissues. Development of vaccines to combat mucosal infections represents a top priority. Mucosal immunization has recently attracted much interest as a means of generating protective immunity against mucosal pathogens.
HARANDI A. M., MEDAGLINI D.
core +7 more sources
Medicine in Drug Discovery, 2021 Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity.
Zhenchuan Wu, Keqin Liu
exaly +3 more sources
Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionVaccine adjuvants enhance immune responses by boosting vaccine efficacy, reducing required doses, and improving long-term immunity. The Vaxjo database is a web-based resource that stores information on vaccine adjuvants, including their names,
Joshua Monickaraj +13 more
doaj +2 more sources
Adjuvant synergy: The effects of nasal coadministration of adjuvants [PDF]
Immunology & Cell Biology, 2004 Modern peptide and protein subunit vaccines suffer from poor immunogenicity and require the use of adjuvants. However, none of the currently licensed adjuvants can elicit cell‐mediated immunity or are suitable for mucosal immunization. In this study we explored the immunological effect of nasal co‐administration of adjuvants with distinct functions ...
S A, Moschos +3 more
openaire +3 more sources
Vaccine adjuvants: mechanisms and platforms [PDF]
Signal Transduction and Targeted Therapy, 2023 Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate immune response controls the antigen-specific ...
Tingmei Zhao +6 more
doaj +2 more sources
Vaccine Potentiation by Combination Adjuvants [PDF]
Vaccines, 2014 Adjuvants are crucial components of vaccines. They significantly improve vaccine efficacy by modulating, enhancing, or extending the immune response and at the same time reducing the amount of antigen needed. In contrast to previously licensed adjuvants,
Benoît Levast +5 more
doaj +2 more sources
Research progress on emulsion vaccine adjuvants [PDF]
HeliyonVaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than ...
Zhuanqing Huang +5 more
doaj +2 more sources
Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions [PDF]
Iranian Journal of Immunology, 2023 The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and provide protection against different kinds of infections.
Arslan Habib +10 more
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Vaccines with adjuvants. Preclinical studies [PDF]
Биопрепараты: Профилактика, диагностика, лечение, 2018 The paper presents the data on safety and efficacy assessment of adjuvants and vaccines with adjuvants at the stages of development and preclinical studies based on international recommendations.
Zh. I. Avdeeva +10 more
doaj +2 more sources
Research Progress of Aluminum Phosphate Adjuvants and Their Action Mechanisms
Pharmaceutics, 2023 Although hundreds of different adjuvants have been tried, aluminum-containing adjuvants are by far the most widely used currently. It is worth mentioning that although aluminum-containing adjuvants have been commonly applied in vaccine production, their ...
Ting Zhang +5 more
doaj +1 more source