Results 41 to 50 of about 104,480 (297)

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Mechanisms of action of adjuvants [PDF]

, 2013
Adjuvants are used in many vaccines, but their mechanisms of action are not fully understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the secrets of adjuvant activity.
George Mutwiri, Lorne A. Babiuk, George eMutwiri, Sunita eAWATE, Lorne A Babiuk, Sunita Awate   +5 more
core   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

The recent advances in vaccine adjuvants

Frontiers in Immunology
Vaccine adjuvants, as key components in enhancing vaccine immunogenicity, play a vital role in modern vaccinology. This review systematically examines the historical evolution and mechanisms of vaccine adjuvants, with particular emphasis on innovative ...
Jiayin Xing, Xiangxiang Zhao, Xiaotian Li, Ren Fang, Mingrui Sun, Yang Zhang, Ningning Song   +6 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Mucosal adjuvants and delivery systems [PDF]

, 2019
Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations
Shivaramaiah, Srichaitanya, Wolfenden, Amanda, Hargis, Billy M., Pumford, Neil R., Morgan, Marion, Tellez, Guillermo L.   +5 more
core   +3 more sources

A living therapeutic platform for localized in situ modulation of macrophage pyroptosis ameliorates GVHD while preserving GVL

Journal of Nanobiotechnology
Background Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation, with the gastrointestinal tract being a primary target organ.
Zhuo Wan, Zhenyu Xu, Xuanting Liang, Yueru Ji, Jiayue Xi, Zhuoyue Shi, Yufei Hou, Xueqian Yan, Nian Li, Li Liu, Chaojun Song, Li Fan, Weiwei Qin   +12 more
doaj   +1 more source

Carbohydrate-Based Adjuvants for Vaccine Production

Биопрепараты: Профилактика, диагностика, лечение, 2018
Addition of adjuvants is a generally recognized method of enhancing the immunogenicity of vaccines. There is a large variety of  adjuvants, therefore the choice of an adjuvant is based on the  comparison of adjuvants efficacy in animal models, as well as 
S. S. Kurashova, T. K. Dzagurova, A. A. Ishmukhametov, M. S. Egorova, M. V. Balovneva, S. E. Sotskova, E. A. Tkachenko   +6 more
doaj   +1 more source

Chitosan-based mucosal adjuvants: Sunrise on the ocean

, 2015
Mucosal vaccination, which is shown to elicit systemic and mucosal immune responses, serves as a non-invasive and convenient alternative to parenteral administration, with stronger capability in combatting diseases at the site of entry.
Fan, Qingze, Wu, Jie, Xia, Yufei, Ma, Guanghui, Su, Zhiguo, Hao, Dongxia   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source