Results 21 to 30 of about 3,884 (159)

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

open access: yesFrontiers in Immunology, 2019
Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to ...
Antonella Riccomi   +5 more
doaj   +1 more source

Military spending, public debt, and economic growth in Cameroon

open access: yesSustainable Futures, 2023
This paper investigates the effect of military spending and public debt on economic growth in Cameroon over the period 1980–2021. Due to the nature of the data, the methodology involves AutoRegressive Distributed Lag (ARDL) models.
Arsène Aurelien Njamen Kengdo
doaj   +1 more source

Drivers of Greek and Turkish Defense Spending

open access: yesInternational Journal of Management and Economics, 2016
This paper evaluates the factors responsible for maintaining substantial military expenditures in Greece and Turkey. The presented research encompasses theoretical and empirical aspects.
Waszkiewicz Grzegorz
doaj   +1 more source

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung [PDF]

open access: yesMucosal Immunology, 2017
The capacity of CD4 T cells to protect against Mycobacterium tuberculosis (Mtb) is governed by their ability to localize to the lung site of infection. Subunit vaccine H56/CAF01, a liposome-adjuvanted fusion protein of Mtb antigens Ag85B, ESAT-6, and Rv2660, conferred durable protection and elicited polyfunctional CD4 T cells that preferentially ...
Woodworth, J.S.   +6 more
openaire   +2 more sources

Business for peace: How entrepreneuring contributes to Sustainable Development Goal 16

open access: yesBusiness Research Quarterly, 2023
We examine entrepreneurial ventures in a post-conflict context to identify practices that are helpful for companies operating in conflict zones while contributing to the United Nations’ Sustainable Development Goal 16 (SDG 16)—Peace, Justice, and Strong ...
Peter Jack Gallo   +2 more
doaj   +1 more source

T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties

open access: yesEBioMedicine, 2018
Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. Here,
Thomas Lindenstrøm   +5 more
doaj   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

open access: yesThe FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy   +7 more
wiley   +1 more source

Synthesis, X‐Ray Analysis, Anticancer Activity, Computational, and in Silico Studies of New Thiophene Pyrazole Conjugates

open access: yesChemistryOpen, Volume 15, Issue 6, June 2026.
Two new thiophene–pyrazole derivatives, 8a and 8b, were synthesized from thiophene 3 precursor and fully characterized. The structure of 8a was confirmed by single‐crystal X‐ray diffraction, which revealed a nonplanar conformation stabilized by NH···O hydrogen bonding and weak intermolecular contacts.
Abdullatif Bin Muhsinah   +3 more
wiley   +1 more source

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

open access: yesVaccines, 2019
Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces   +4 more
doaj   +1 more source

Ampelopsis Grossedentata Flavonoids Alleviate Hepatic Damage Through Remodeling Intestinal Microflora and Reducing Oxidative Stress in Rats

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the multi‐target antioxidant and anti‐inflammatory effects of AGF in alleviating liver injury, and their association with gut microbiota modulation and enrichment of beneficial microbes. ABSTRACT To investigate the antioxidant effects and underlying mechanisms of Ampelopsis grossedentata flavonoids (AGF) in rats fed ...
Hao Shi, Bo Zhou, Jing Wang, Li Lan Lei
wiley   +1 more source

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