Results 41 to 50 of about 3,884 (159)

Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

Scientific Reports, 2017
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro.
Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald   +4 more
doaj   +1 more source

Pleistocene Climate Changes and Lineage Diversification of Sphenarium Grasshoppers (Orthoptera: Pyrgomorphidae)

Ecology and Evolution, Volume 15, Issue 10, October 2025.
We investigate the phylogeographic history and paleodistribution patterns of four closely related grasshopper species of the genus Sphenarium to test the relative impact of Pleistocene climate fluctuations on their diversification. We found that each species responded differently to these fluctuations, but their divergence, distribution, and ...
Salomón Sanabria‐Urbán, Andrés Torres‐Miranda, David A. Prieto‐Torres, Ken Oyama, Raúl Cueva del Castillo   +4 more
wiley   +1 more source

Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection [PDF]

Mucosal Immunology, 2019
T cell-mediated protection against Mycobacterium tuberculosis (Mtb) is dependent upon the ability to localize within the site of pulmonary infection and directly interact with infected cells. In turn, vaccine strategies to improve rapid T cell targeting of Mtb-infected cells after pulmonary exposure are being actively pursued.
Woodworth, Joshua S., Christensen, Dennis, Cassidy, Joseph P., Agger, Else Marie, Mortensen, Rasmus, Andersen, Peter   +5 more
openaire   +4 more sources

Unstained Blood Smear Analysis: A Review of Rule‐Based, Machine Learning, and Deep Learning Techniques

Journal of Biophotonics, Volume 18, Issue 10, October 2025.
Bright‐field images of unstained smears. (1) Sparse erythrocytes allow straightforward intensity‐ or phase‐based segmentation. (2) Overlapping cells blur boundaries, causing over‐ or under‐segmentation and lowering rule‐based accuracy, thus motivating overlap‐aware algorithms for reliable downstream feature extraction and classification. ABSTRACT Blood
Husnu Baris Baydargil, Thomas Bocklitz
wiley   +1 more source

EFFECT OF H56/28 (APTINE) ON CATECHOLAMINE‐INDUCED ARRHYTHMIAS AND NEUROMUSCULAR TRANSMISSION IN MAN

Acta Anaesthesiologica Scandinavica, 1969
SUMMARYThe beta adrenergic blocking agent H56/28 was found to be effective in the prevention of catecholamine‐anesthetic cardiac arrhythmias in man. It was suggested that this antiarrhythmic action was due to beta adrenergic blockade rather than the local anesthetic activity which H56/28 is known to possess.
openaire   +3 more sources

Analysis of gene expression profiles in two spinal cord injury models

European Journal of Medical Research, 2022
Objectives To analyze the changes of gene expression at different timepoints after spinal cord injury (SCI) with tenth segment thoracic injury. Methods Two SCI models, the complete paraplegia (H) and Allen’s strike (D) methods were applied to induce SCI ...
Haifeng Yuan, Bi Zhang, Junchi Ma, Yufei Zhang, Yifan Tuo, Xusheng Li   +5 more
doaj   +1 more source

Complex population genetic structure of the bark beetle predator Thanasimus formicarius (L.) (Coleoptera: Cleridae) across its European range

Agricultural and Forest Entomology, Volume 27, Issue 3, Page 437-451, August 2025.
Abstract Thanasimus formicarius (L.) (Coleoptera: Cleridae) is an important bark beetle predator and can reduce bark beetle population densities of some of the most severe forest pests in Europe. We analysed the population genetics and phylogeography of T.
Eva Papek, Amina Derlić, Markus Melin, Alain Roques, Dragos Cocos, Martin L. Schroeder, Milan Pernek, Dimitrios N. Avtzis, Paulius Zolubas, David T. Williams, Juan A. Pajares, Oğuzhan Sarikaya, Roman Pavlin, Sevdalin Belilov, Martin M. Gossner, M. Lukas Seehausen, Anna Wierzbicka, Lara Kundtner, Christian Stauffer, Martin Schebeck   +19 more
wiley   +1 more source

National Security Issues in War Conditions – The Case of Ukraine: Economic and Environmental Dimensions

Review of Economic Perspectives
The relevance of this research topic sustertems from the emergence of a whole range of systemic risks and threats resulting from the war in Ukraine. Russia’s full-scale aggression has exacerbated existing crises and given rise to new challenges in the ...
Iermakova Olga, Sokoliuk Kateryna, Shershun Olha   +2 more
doaj   +1 more source

Positive selection within the Schizophrenia-associated GABA(A) receptor beta(2) gene. [PDF]

PLoS ONE, 2007
The gamma-aminobutyric acid type-A (GABA(A)) receptor plays a major role in inhibitory neurotransmissions. Intronic SNPs and haplotypes in GABRB2, the gene for GABA(A) receptor beta(2) subunit, are associated with schizophrenia and correlated with the ...
Wing-Sze Lo, Zhiwen Xu, Zhiliang Yu, Frank W Pun, Siu-Kin Ng, Jianhuan Chen, Ka-Lok Tong, Cunyou Zhao, Xiaojing Xu, Shui-Ying Tsang, Mutsuo Harano, Gerald Stöber, Vishwajit L Nimgaonkar, Hong Xue   +13 more
doaj   +1 more source

Replacement of large subunit N terminus enabled biogenesis of different plant Rubiscos in E. coli

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3382-3391, August 2025.
Summary The efforts of engineering plant ribulose‐1,5‐bisphosphate carboxylase/oxygenase (Rubisco) with the goal of improving plant photosynthetic efficiency and crop yield have existed for long. However, the directed evolution of plant Rubisco has not been widely explored because its biogenesis in a heterologous host such as Escherichia coli remains ...
Zhen Cai, Lei Zhao, Kailu Ma, Guoxia Liu, Junli Zhang, Fuyu Gong, Wanli Pei, Lu Xiao, Yin Li   +8 more
wiley   +1 more source