Results 61 to 70 of about 4,028 (164)
ChemBioChem, Volume 26, Issue 8, April 14, 2025.The inhibition of CAC transporter, an important mitochondrial protein, by Pr3+, Gd3+ and Tm3+ lanthanides is studied in the framework of all‐atoms MD simulations. In presence of cations, it is shown that c‐state to m‐state conformational change occurs spontaneously, providing atomistic explanation of the protein's channel occlusion and inhibition ...
Mario Prejanò +4 more
wiley +1 more source
Vaccine, 2016 In vaccine development, dose-response curves are commonly assumed to be saturating. Evidence from tuberculosis (TB) vaccine, H56+IC31 shows this may be incorrect. Mathematical modelling techniques may be useful in efficiently identifying the most immunogenic dose, but model calibration requires longitudinal data across multiple doses and time points.We
Rhodes, SJ +8 more
openaire +3 more sources
Advanced Science, Volume 12, Issue 11, March 20, 2025.This study reveals that obesity‐driven metabolic dysfunction enhances YAP O‐GlcNAcylation, facilitating its stabilization by preventing ubiquitylation and degradation via EIF3H, thereby driving TNBC progression and chemoresistance. Retatrutide disrupts this axis by suppressing O‐GlcNAcylation, restoring YAP ubiquitylation, and enhancing degradation ...
Xin Cui +9 more
wiley +1 more source
Influence of selected Rhizoctonia solani isolates on sugar beet seedlings
Journal of Plant Protection Research, 2016 From 2008 to 2010 the levels of sugar beet seedlings infection caused by Rhizoctonia solani were compared in laboratory tests. Seven sugar beet lines were tested: H56, H66, S2, S3, S4, S5 and S6 as well as three control cultivars: Carlos, Esperanza and ...
Skonieczek Paweł +4 more
doaj +1 more source
Ecology and Evolution, Volume 15, Issue 2, February 2025.Our molecular genetic analyses provide resolution for the controversial status of jebeer and chinkara, providing a basis for future assessments by the IUCN and national authorities in Iran. Furthermore, these data enable us to make informed decisions regarding crucial areas of jebeer conservation.
Davoud Fadakar +5 more
wiley +1 more source
High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
Frontiers in Immunology, 2018 Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these ...
Rolf Billeskov +8 more
doaj +1 more source
FEBS Letters, Volume 599, Issue 1, Page 41-52, January 2025.Zinc transporters (ZnTs) function as H+/Zn2+ antiporters, facilitating zinc efflux from the cytosol to the extracellular space or intracellular vesicles, playing a crucial role in maintaining zinc homeostasis. Here, using cryo‐electron microscopy, we characterized the structures of ZnT3 (inward‐facing) and ZnT4 (outward‐facing), providing insights into
Hanako Ishida +4 more
wiley +1 more source
The price of backlash: Performance of Israeli firms Post-Gaza War
Borsa Istanbul ReviewThis study examines the financial price of reputational backlash against Israeli firms following the Gaza War on October 7, 2023. We develop a sentiment–trade interaction framework that integrates Google Trends hostility queries, GDELT media tone, and a ...
Ihlas Sovbetov
doaj +1 more source
HeliyonThis study examines the economic impact of soaring international energy prices during the Russia-Ukraine conflict from February 23, 2022, to May 31, 2022.
Mingsong Sun +4 more
doaj +1 more source
Vaccine, 2015 CD4(+) T-cell priming is an essential step in vaccination due to the key role of T helper cells in driving both effector and memory immune responses. Here we have characterized in C57BL/6 mice the T helper subtype differentiation among tetramer-specific CD4(+) T cells primed by subcutaneous immunization with the tuberculosis vaccine antigen H56 plus ...
Prota, Gennaro +4 more
openaire +4 more sources