Results 1 to 10 of about 583 (106)

Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells [PDF]

Frontiers in Immunology
Successful induction of protective T cells by recombinant protein vaccines requires adjuvants. The liposomal adjuvant system CAF01 induces robust Th17 responses in mice.
Robert Blamberg, Carl Haberkamp, Gabriel Kristian Pedersen, Ida Rosenkrands, Ulrike Schleicher, Ulrike Schleicher, Barbara U. Schraml, Sho Yamasaki, Roland Lang, Roland Lang   +9 more
doaj   +2 more sources

C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates [PDF]

Frontiers in Immunology, 2023
IntroductionC-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults.MethodsHere, we explored the ...
Maria Vono, Beatris Mastelic-Gavillet, Elodie Mohr, Malin Östensson, Josefine Persson, Thorunn A. Olafsdottir, Sylvain Lemeille, David Pejoski, Oliver Hartley, Dennis Christensen, Peter Andersen, Arnaud M. Didierlaurent, Ali M. Harandi, Ali M. Harandi, Paul-Henri Lambert, Claire-Anne Siegrist   +15 more
doaj   +2 more sources

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [PDF]

Frontiers in Immunology
IntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways.
Ranmali Kavishna, Thorunn Asta Olafsdottir, Siggeir F. Brynjólfsson, Dennis Christensen, Tobias Gustafsson-Hedberg, Peter Andersen, Manuela Terrinoni, Jan Holmgren, Ali M. Harandi, Ali M. Harandi   +9 more
doaj   +2 more sources

CAF01 Potentiates Immune Responses and Efficacy of an Inactivated Influenza Vaccine in Ferrets [PDF]

PLoS ONE, 2011
Trivalent inactivated vaccines (TIV) against influenza are given to 350 million people every year. Most of these are non-adjuvanted vaccines whose immunogenicity and protective efficacy are considered suboptimal. Commercially available non-adjuvanted TIV
Trine Hammer Jensen, Peter Andersen, Lars Andresen   +2 more
exaly   +2 more sources

Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model [PDF]

Frontiers in Immunology
Childhood vaccination provides protection against infectious diseases, but multiple vaccinations are required to achieve this. In situations like influenza epidemics or COVID-19 pandemic, vaccine demands may exceed production capacity, highlighting the ...
Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Gabriel Kristian Pedersen, Dennis Christensen, Serena Marchi, Emanuele Montomoli, Emanuele Montomoli, Stefanía P. Bjarnarson, Stefanía P. Bjarnarson, Ingileif Jonsdottir, Ingileif Jonsdottir, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind   +14 more
doaj   +2 more sources

Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01 [PDF]

PLoS ONE, 2014
The development of new low cost inactivated polio virus based vaccines (IPV) is a high priority, and will be required to eradicate polio. In addition, such a vaccine constitutes the only realistic polio vaccine in the post-eradication era.
Jes Dietrich, Peter Andersen, Else Marie Agger   +2 more
exaly   +2 more sources

A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models [PDF]

mBio, 2023
Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth, Mei-Fong Ho, Mehfuz Zaman, Emily Cooper, Priyanka Som, Mark Burgess, Maddison Walton, Reshma J. Nevagi, Lynette Beattie, Declan Murphy, Danielle I. Stanisic, Michael F. Good   +11 more
doaj   +2 more sources

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model [PDF]

Frontiers in Immunology, 2022
It is of international priority to develop a vaccine against sexually transmitted Chlamydia trachomatis infections to combat the continued global spread of the infection. The optimal immunization strategy still remains to be fully elucidated.
Emma Lorenzen, Vanessa Contreras, Anja W. Olsen, Peter Andersen, Delphine Desjardins, Ida Rosenkrands, Helene Bæk Juel, Benoit Delache, Sebastien Langlois, Constance Delaugerre, Christophe Joubert, Nathalie Dereuddre-Bosquet, Cécile Bébéar, Bertille De Barbeyrac, Arabella Touati, Paul F. McKay, Robin J. Shattock, Roger Le Grand, Frank Follmann, Jes Dietrich   +19 more
doaj   +2 more sources

Induction of mucosal immune responses against SARS-CoV-2: a heterologous intramuscular mRNA-LNP prime/pulmonary recombinant subunit pull vaccination strategy [PDF]

Scientific Reports
Approved mRNA vaccines administered intramuscularly (i.m.) induce strong systemic immune responses, but provide limited protection at the respiratory mucosa, where many infections are initiated.
Melike Ongun, Naga Suresh Kola, Dhruv Patel, Tasson da Costa Rodrigues, Signe Tandrup Schmidt, Abhijeet Girish Lokras, Henrik Franzyk, Søren R. Paludan, Thomas Rades, Aneesh Thakur, Camilla Foged   +10 more
doaj   +2 more sources

Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques [PDF]

eLife
CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response.
Anil Verma, Chase E Hawes, Sonny R Elizaldi, Justin C Smith, Dhivyaa Rajasundaram, Gabriel Kristian Pedersen, Xiaoying Shen, LaTonya D Williams, Georgia D Tomaras, Pamela A Kozlowski, Rama R Amara, Smita S Iyer   +11 more
doaj   +2 more sources