Sublingual Boosting with a Novel Mucoadhesive Thermogelling Hydrogel Following Parenteral CAF01 Priming as a Strategy Against Chlamydia trachomatis. [PDF]
Adv Healthc Mater, 2022 The optimal thermosensitive, mucoadhesive and stable hydrogel (OGEL) developed through artificial intelligence tools within the concept of “Quality by Design” is useful as a carrier for chlamydia subunit vaccine CTH522. The sublingual administration of OGEL/CTH522, after parenteral immunization with CAF01/CTH522 (cationic liposomes), promotes Th1&Th17 ...
Garcia-Del Rio L +4 more
europepmc +8 more sources
Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone [PDF]
Frontiers in Immunology, 2020 Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and ...
Aneesh Thakur +2 more
exaly +10 more sources
CAF01 Potentiates Immune Responses and Efficacy of an Inactivated Influenza Vaccine in Ferrets [PDF]
PLoS ONE, 2011 Trivalent inactivated vaccines (TIV) against influenza are given to 350 million people every year. Most of these are non-adjuvanted vaccines whose immunogenicity and protective efficacy are considered suboptimal. Commercially available non-adjuvanted TIV
Trine Hammer Jensen +2 more
exaly +7 more sources
Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate [PDF]
Veterinary Research, 2020 Conserved epitopes are targets commonly researched to be part of universal vaccine candidates against influenza viruses (IV). These conserved epitopes need to be cross-protecting against distinct IV subtypes and to have a strong immunogenic potential ...
Marta Sisteré-Oró +5 more
doaj +12 more sources
Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01 [PDF]
PLoS ONE, 2014 The development of new low cost inactivated polio virus based vaccines (IPV) is a high priority, and will be required to eradicate polio. In addition, such a vaccine constitutes the only realistic polio vaccine in the post-eradication era.
Jes Dietrich, Peter Andersen
exaly +5 more sources
Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes [PDF]
Frontiers in Immunology, 2015 The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines.
Annalisa Ciabattini +2 more
exaly +7 more sources
BpOmpW antigen administered with CAF01 adjuvant stimulates comparable T cell responses to Sigma adjuvant system [PDF]
Vaccine: XThere are no licensed vaccines to protect vulnerable populations from the potentially fatal tropical infection, melioidosis, despite its causative agent, Burkholderia pseudomallei, being endemic in tropical and subtropical regions.
Julen Tomás-Cortázar +5 more
doaj +4 more sources
Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization [PDF]
Frontiers in Immunology, 2018 Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Aneesh Thakur +2 more
exaly +7 more sources
A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models [PDF]
mBio, 2023 Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth +11 more
doaj +5 more sources
C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates [PDF]
Frontiers in Immunology, 2023 IntroductionC-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults.MethodsHere, we explored the ...
Maria Vono +15 more
doaj +2 more sources