Results 11 to 20 of about 584 (117)

A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models [PDF]

mBio, 2023
Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth, Mei-Fong Ho, Mehfuz Zaman, Emily Cooper, Priyanka Som, Mark Burgess, Maddison Walton, Reshma J. Nevagi, Lynette Beattie, Declan Murphy, Danielle I. Stanisic, Michael F. Good   +11 more
doaj   +2 more sources

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Frontiers in Immunology, 2018
Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Peter Andersen   +2 more
exaly   +3 more sources

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model [PDF]

Frontiers in Immunology, 2022
It is of international priority to develop a vaccine against sexually transmitted Chlamydia trachomatis infections to combat the continued global spread of the infection. The optimal immunization strategy still remains to be fully elucidated.
Emma Lorenzen, Vanessa Contreras, Anja W. Olsen, Peter Andersen, Delphine Desjardins, Ida Rosenkrands, Helene Bæk Juel, Benoit Delache, Sebastien Langlois, Constance Delaugerre, Christophe Joubert, Nathalie Dereuddre-Bosquet, Cécile Bébéar, Bertille De Barbeyrac, Arabella Touati, Paul F. McKay, Robin J. Shattock, Roger Le Grand, Frank Follmann, Jes Dietrich   +19 more
doaj   +2 more sources

Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques [PDF]

eLife
CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response.
Anil Verma, Chase E Hawes, Sonny R Elizaldi, Justin C Smith, Dhivyaa Rajasundaram, Gabriel Kristian Pedersen, Xiaoying Shen, LaTonya D Williams, Georgia D Tomaras, Pamela A Kozlowski, Rama R Amara, Smita S Iyer   +11 more
doaj   +2 more sources

BpOmpW antigen administered with CAF01 adjuvant stimulates comparable T cell responses to Sigma adjuvant system [PDF]

Vaccine: X
There are no licensed vaccines to protect vulnerable populations from the potentially fatal tropical infection, melioidosis, despite its causative agent, Burkholderia pseudomallei, being endemic in tropical and subtropical regions.
Julen Tomás-Cortázar, Conor Quinn, Niamh Corcoran, Alfonso Blanco, Dennis Christensen, Siobhán McClean   +5 more
doaj   +2 more sources

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy [PDF]

npj Vaccines, 2023
Staphylococcus aureus infections are a major public health issue, and a vaccine is urgently needed. Despite a considerable promise in preclinical models, all vaccines tested thus far have failed to protect humans against S. aureus. Unlike laboratory mice,
Omid Teymournejad, Zhaotao Li, Pavani Beesetty, Ching Yang, Christopher P. Montgomery   +4 more
doaj   +2 more sources

Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes

Frontiers in Immunology, 2015
The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines.
Annalisa Ciabattini, Peter Andersen, Gianni Pozzi   +2 more
exaly   +3 more sources

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines. [PDF]

PLoS Pathogens
The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CAF01).
Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz   +6 more
doaj   +2 more sources

Next-generation Candida albicans vaccine VXV-01 containing recombinant Als3p and Hyr1p antigens for invasive Candida infections [PDF]

Scientific Reports
Candida species, including Candida albicans and Candida auris, represent a growing public health concern due to their increasing prevalence and resistance to antifungal agents. C.
Shakti Singh, Eman G. Youssef, Ashley Barbarino, Haley Hautau, Sunna Nabeela, Teclegiorgis Gebremariam, Sondus Alkhazraji, Gary Ostroff, Dennis Christensen, Terrence Cochrane, Ashraf S. Ibrahim   +10 more
doaj   +2 more sources

H65 fusion protein fails to improve the protection of a rationally attenuated live vaccine candidate against bovine tuberculosis in a mouse model of tuberculosis

International Journal of Mycobacteriology, 2021
Background: The fusion protein H65, composed of Mycobacterium tuberculosis (TB) ESX-secreted antigens, has improved the bacillus Calmette–Guerin-induced immune protection in a mouse model of bovine TB when formulated in the liposomal adjuvant CAF01.
Elizabeth A García, Federico C Blanco, Fabiana Bigi   +2 more
doaj   +1 more source