BpOmpW antigen administered with CAF01 adjuvant stimulates comparable T cell responses to Sigma adjuvant system [PDF]
Vaccine: XThere are no licensed vaccines to protect vulnerable populations from the potentially fatal tropical infection, melioidosis, despite its causative agent, Burkholderia pseudomallei, being endemic in tropical and subtropical regions.
Julen Tomás-Cortázar +5 more
doaj +3 more sources
Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. [PDF]
PLoS ONE, 2008 BACKGROUND: It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for adequate
Else Marie Agger +12 more
doaj +4 more sources
Sublingual Boosting with a Novel Mucoadhesive Thermogelling Hydrogel Following Parenteral CAF01 Priming as a Strategy Against Chlamydia trachomatis. [PDF]
Adv Healthc Mater, 2022 The optimal thermosensitive, mucoadhesive and stable hydrogel (OGEL) developed through artificial intelligence tools within the concept of “Quality by Design” is useful as a carrier for chlamydia subunit vaccine CTH522. The sublingual administration of OGEL/CTH522, after parenteral immunization with CAF01/CTH522 (cationic liposomes), promotes Th1&Th17 ...
Garcia-Del Rio L +4 more
europepmc +4 more sources
Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone [PDF]
Frontiers in Immunology, 2020 Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and ...
Aneesh Thakur +6 more
doaj +2 more sources
Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate [PDF]
Veterinary Research, 2020 Conserved epitopes are targets commonly researched to be part of universal vaccine candidates against influenza viruses (IV). These conserved epitopes need to be cross-protecting against distinct IV subtypes and to have a strong immunogenic potential ...
Marta Sisteré-Oró +5 more
doaj +2 more sources
Journal of Fungi, 2020 The peptide P10 is a vaccine candidate for Paracoccidioidomycosis, a systemic mycosis caused by fungal species of the genus Paracoccidioides spp. We have previously shown that peptide P10 vaccination, in the presence of several different adjuvants ...
Marcelo Valdemir de Araújo +3 more
doaj +2 more sources
A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. [PDF]
PLoS ONE, 2009 BACKGROUND:Specific cellular cytotoxic immune responses (CTL) are important in combating viral diseases and a highly desirable feature in the development of targeted HIV vaccines. Adjuvants are key components in vaccines and may assist the HIV immunogens
Gregers Jacob Gram +4 more
doaj +2 more sources
Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization [PDF]
Frontiers in Immunology, 2018 Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Aneesh Thakur +10 more
doaj +2 more sources
Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant [PDF]
Frontiers in Immunology, 2018 Influenza epidemics occur annually, and estimated 5–10% of the adult population and 20–30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal ...
Dennis Christensen +6 more
doaj +2 more sources
A multi‐subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN‐γ+ CMI responses protects against a genital infection in minipigs [PDF]
Immunology &Cell Biology, Volume 94, Issue 2, Page 185-195, February 2016., 2016 Chlamydia is the most widespread sexually transmitted bacterial disease and a prophylactic vaccine is highly needed. Ideally, this vaccine is required to induce a combined response of Th1 cell‐mediated immune (CMI) response in concert with neutralizing antibodies.
Sarah Bøje +6 more
wiley +2 more sources