Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant [PDF]
Frontiers in Immunology, 2018 Influenza epidemics occur annually, and estimated 5–10% of the adult population and 20–30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal ...
Dennis Christensen +6 more
doaj +8 more sources
Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection [PDF]
Mucosal Immunology, 2019 T cell-mediated protection against Mycobacterium tuberculosis (Mtb) is dependent upon the ability to localize within the site of pulmonary infection and directly interact with infected cells. In turn, vaccine strategies to improve rapid T cell targeting of Mtb-infected cells after pulmonary exposure are being actively pursued.
Joshua S Woodworth +2 more
exaly +8 more sources
Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial [PDF]
Lancet Infectious Diseases, The, 2019 Chlamydia is the most common sexually transmitted bacterial infection worldwide. National screening programmes and antibiotic treatment have failed to decrease incidence, and to date no vaccines against genital chlamydia have been tested in clinical trials.
Peter Bang +2 more
exaly +6 more sources
Liposomal delivery system/adjuvant for tuberculosis vaccine. [PDF]
Immun Inflamm Dis, 2023 The delivery system and safety regulator are common characteristics of effective adjuvants in tuberculosis (TB) vaccines and the clinical trial stage. Based on our findings, the liposomal system is a superb adjuvant for vaccinations against TB, other intracellular infections, and malignancies.
Moradi M +9 more
europepmc +2 more sources
Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [PDF]
Frontiers in ImmunologyIntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways.
Ranmali Kavishna +9 more
doaj +2 more sources
Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells [PDF]
Frontiers in ImmunologySuccessful induction of protective T cells by recombinant protein vaccines requires adjuvants. The liposomal adjuvant system CAF01 induces robust Th17 responses in mice.
Robert Blamberg +9 more
doaj +2 more sources
Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. [PDF]
PLoS ONE, 2008 BACKGROUND: It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for adequate
Else Marie Agger +12 more
doaj +4 more sources
Therapeutic Vaccination with Cationic Liposomes Formulated with Dioctadecyldimethylammonium and Trehalose Dibehenate (CAF01) and Peptide P10 Is Protective in Mice Infected with Paracoccidioides brasiliensis [PDF]
Journal of Fungi, 2020 The peptide P10 is a vaccine candidate for Paracoccidioidomycosis, a systemic mycosis caused by fungal species of the genus Paracoccidioides spp. We have previously shown that peptide P10 vaccination, in the presence of several different adjuvants ...
Marcelo Valdemir de Araújo +3 more
doaj +3 more sources
Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model [PDF]
Frontiers in ImmunologyChildhood vaccination provides protection against infectious diseases, but multiple vaccinations are required to achieve this. In situations like influenza epidemics or COVID-19 pandemic, vaccine demands may exceed production capacity, highlighting the ...
Jenny Lorena Molina Estupiñan +14 more
doaj +2 more sources
A multi‐subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN‐γ+ CMI responses protects against a genital infection in minipigs [PDF]
Immunology &Cell Biology, Volume 94, Issue 2, Page 185-195, February 2016., 2016 Chlamydia is the most widespread sexually transmitted bacterial disease and a prophylactic vaccine is highly needed. Ideally, this vaccine is required to induce a combined response of Th1 cell‐mediated immune (CMI) response in concert with neutralizing antibodies.
Sarah Bøje +6 more
wiley +4 more sources